• Je něco špatně v tomto záznamu ?

Markers of nucleic acids and proteins oxidation among office workers exposed to air pollutants including (nano)TiO2 particles

D. Pelclova, V. Zdimal, P. Kacer, S. Vlckova, Z. Fenclova, T. Navratil, M. Komarc, J. Schwarz, N. Zikova, O. Makes, S. Zakharov,

. 2016 ; 37 (Suppl1) : 13-16.

Jazyk angličtina Země Švédsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc17023238

OBJECTIVES: Experimental studies using nanoscale TiO2 have documented lung injury, inflammation, oxidative stress, and genotoxicity. Human health data are extremely scarce. METHODS: In exhaled breath condensate (EBC) and urine of 22 office employees occupationally exposed to TiO2 during their visit in the production workshops for average 14±9 min/day a panel of biomarkers of nucleic acids and proteins oxidation was studied, specifically 8-hydroxy-2-deoxyguanosine (8-OHdG), 8-hydroxyguanosine (8-OHG), 5-hydroxymethyl uracil (5-OHMeU), o-tyrosine (o-Tyr), 3-chlorotyrosine (3-ClTyr), and 3-nitrotyrosine (3-NOTyr). Examination was performed also in 14 comparable controls. RESULTS: The median respirable TiO2 mass concentration in the workshops was 0.40 mg/m3, median number concentration was 2.32×104 particles/cm3 with 80% of the particles being <100 nm in diameter. All 6 markers of oxidation were elevated in EBC in factory office employees relative to controls (p<0.01). Significant association was found between their job in TiO2 production plant and 5 markers of oxidation (except 3-NOTyr) in the EBC in multivariate analysis. No elevation of markers was detected in the urine. CONCLUSION: This pilot study suggests that even short nanoTiO2 exposure may lead to pulmonary oxidative stress; however this effect may be short-term and reversible. The clinical significance of these findings is unclear and more studies are needed.

000      
00000naa a2200000 a 4500
001      
bmc17023238
003      
CZ-PrNML
005      
20250403084551.0
007      
ta
008      
170720s2016 sw f 000 0|eng||
009      
AR
035    __
$a (PubMed)28263525
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sw
100    1_
$a Pelclova, Daniela $u Charles University and General University Hospital in Prague, 1st Faculty of Medicine, Department of Occupational Medicine, Prague, Czech Republic.
245    10
$a Markers of nucleic acids and proteins oxidation among office workers exposed to air pollutants including (nano)TiO2 particles / $c D. Pelclova, V. Zdimal, P. Kacer, S. Vlckova, Z. Fenclova, T. Navratil, M. Komarc, J. Schwarz, N. Zikova, O. Makes, S. Zakharov,
520    9_
$a OBJECTIVES: Experimental studies using nanoscale TiO2 have documented lung injury, inflammation, oxidative stress, and genotoxicity. Human health data are extremely scarce. METHODS: In exhaled breath condensate (EBC) and urine of 22 office employees occupationally exposed to TiO2 during their visit in the production workshops for average 14±9 min/day a panel of biomarkers of nucleic acids and proteins oxidation was studied, specifically 8-hydroxy-2-deoxyguanosine (8-OHdG), 8-hydroxyguanosine (8-OHG), 5-hydroxymethyl uracil (5-OHMeU), o-tyrosine (o-Tyr), 3-chlorotyrosine (3-ClTyr), and 3-nitrotyrosine (3-NOTyr). Examination was performed also in 14 comparable controls. RESULTS: The median respirable TiO2 mass concentration in the workshops was 0.40 mg/m3, median number concentration was 2.32×104 particles/cm3 with 80% of the particles being <100 nm in diameter. All 6 markers of oxidation were elevated in EBC in factory office employees relative to controls (p<0.01). Significant association was found between their job in TiO2 production plant and 5 markers of oxidation (except 3-NOTyr) in the EBC in multivariate analysis. No elevation of markers was detected in the urine. CONCLUSION: This pilot study suggests that even short nanoTiO2 exposure may lead to pulmonary oxidative stress; however this effect may be short-term and reversible. The clinical significance of these findings is unclear and more studies are needed.
650    _2
$a dospělí $7 D000328
650    _2
$a látky znečišťující vzduch $x škodlivé účinky $7 D000393
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a kovové nanočástice $x škodlivé účinky $7 D053768
650    _2
$a lidé středního věku $7 D008875
650    _2
$a nemoci z povolání $x krev $7 D009784
650    _2
$a pracovní expozice $x škodlivé účinky $7 D016273
650    12
$a oxidační stres $7 D018384
650    _2
$a pilotní projekty $7 D010865
650    _2
$a titan $x škodlivé účinky $7 D014025
655    _2
$a časopisecké články $7 D016428
700    1_
$a Zdimal, Vladimir $u Institute of Chemical Process Fundamentals of the CAS CR, v.v.i., Prague, Czech Republic.
700    1_
$a Kacer, Petr $u Institute of Chemical Technology Prague, Czech Republic.
700    1_
$a Vlckova, Stepanka $u Charles University and General University Hospital in Prague, 1st Faculty of Medicine, Department of Occupational Medicine, Prague, Czech Republic.
700    1_
$a Fenclová, Zdeňka, $d 1958- $u Charles University and General University Hospital in Prague, 1st Faculty of Medicine, Department of Occupational Medicine, Prague, Czech Republic. $7 xx0074215
700    1_
$a Navratil, Tomas $u J. Heyrovský Institute of Physical Chemistry of the CAS CR, v.v.i., Prague, Czech Republic.
700    1_
$a Komarc, Martin $u Charles University, Faculty of Physical Education and Sport, Department of Kinanthropology and Humanities, Prague, Czech Republic. Charles University, 1st Faculty of Medicine, Institute of Biophysics and Informatics, Prague, Czech Republic.
700    1_
$a Schwarz, Jaroslav $u Institute of Chemical Process Fundamentals of the CAS CR, v.v.i., Prague, Czech Republic.
700    1_
$a Zikova, Nadezda $u Institute of Chemical Process Fundamentals of the CAS CR, v.v.i., Prague, Czech Republic.
700    1_
$a Makes, Otakar $u Institute of Chemical Process Fundamentals of the CAS CR, v.v.i., Prague, Czech Republic.
700    1_
$a Zakharov, Sergey $u Charles University and General University Hospital in Prague, 1st Faculty of Medicine, Department of Occupational Medicine, Prague, Czech Republic.
773    0_
$w MED00168352 $t Neuro-endocrinology letters $x 0172-780X $g Roč. 37, Suppl1 (2016), s. 13-16
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28263525 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20170720 $b ABA008
991    __
$a 20250403084546 $b ABA008
999    __
$a ok $b bmc $g 1238919 $s 984151
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2016 $b 37 $c Suppl1 $d 13-16 $i 0172-780X $m Neuro-endocrinology letters $n Neuro-endocrinol. lett. $x MED00168352
LZP    __
$a Pubmed-20170720

Najít záznam

Citační ukazatele

    Možnosti archivace