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The "Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies" (SPRINTT) randomized controlled trial: design and methods
F. Landi, M. Cesari, R. Calvani, A. Cherubini, M. Di Bari, R. Bejuit, J. Mshid, S. Andrieu, AJ. Sinclair, CC. Sieber, B. Vellas, E. Topinkova, T. Strandberg, L. Rodriguez-Manas, F. Lattanzio, M. Pahor, R. Roubenoff, AJ. Cruz-Jentoft, R. Bernabei,...
Language English Country Germany
Document type Clinical Trial, Phase III, Journal Article, Multicenter Study, Randomized Controlled Trial
NLK
ProQuest Central
from 1997-02-01 to 1 year ago
Health & Medicine (ProQuest)
from 1997-02-01 to 1 year ago
- MeSH
- Cost-Benefit Analysis MeSH
- Exercise * MeSH
- Frail Elderly * MeSH
- Quality of Life MeSH
- Humans MeSH
- Mobility Limitation * MeSH
- Sarcopenia prevention & control therapy MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Aging MeSH
- Accidental Falls prevention & control MeSH
- Research Design MeSH
- Check Tag
- Humans MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Publication type
- Journal Article MeSH
- Clinical Trial, Phase III MeSH
- Multicenter Study MeSH
- Randomized Controlled Trial MeSH
The sustainability of health and social care systems is threatened by a growing population of older persons with heterogeneous needs related to multimorbidity, frailty, and increased risk of functional impairment. Since disability is difficult to reverse in old age and is extremely burdensome for individuals and society, novel strategies should be devised to preserve adequate levels of function and independence in late life. The development of mobility disability, an early event in the disablement process, precedes and predicts more severe forms of inability. Its prevention is, therefore, critical to impede the transition to overt disability. For this reason, the Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies (SPRINTT) project is conducting a randomized controlled trial (RCT) to test a multicomponent intervention (MCI) specifically designed to prevent mobility disability in high-risk older persons. SPRINTT is a phase III, multicenter RCT aimed at comparing the efficacy of a MCI, based on long-term structured physical activity, nutritional counseling/dietary intervention, and an information and communication technology intervention, versus a healthy aging lifestyle education program designed to prevent mobility disability in 1500 older persons with physical frailty and sarcopenia who will be followed for up to 36 months. The primary outcome of the SPRINTT trial is mobility disability, operationalized as the inability to walk for 400 m within 15 min, without sitting, help of another person, or the use of a walker. Secondary outcomes include changes in muscle mass and strength, persistent mobility disability, falls and injurious falls, disability in activities of daily living, nutritional status, cognition, mood, the use of healthcare resources, cost-effectiveness analysis, quality of life, and mortality rate. SPRINTT results are expected to promote significant advancements in the management of frail older persons at high risk of disability from both clinical and regulatory perspectives. The findings are also projected to pave the way for major investments in the field of disability prevention in old age.
Department of Aging and Geriatric Research University of Florida Gainesville FL USA
Department of Geriatrics 1st Faculty of Medicine Charles University Prague Czech Republic
Foundation for Diabetes Research in Older People Diabetes Frail Ltd Droitwich Spa UK
Geriatric Department University Hospital Ramón y Cajal Madrid Spain
Geriatrics and Geriatric Emergency Care IRCCS INRCA Ancona Italy
Gérontopôle Centre Hospitalier Universitaire de Toulouse Toulouse France
Global Translational Medicine Novartis Institutes for Biomedical Research Basel Switzerland
Institute for Biomedicine of Aging Friedrich Alexander University Nuremberg Germany
Sanofi R and D Paris Chilly Mazarin France
Service of Geriatrics Getafe University Hospital Madrid Spain
References provided by Crossref.org
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