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Alcohol and lung cancer risk among never smokers: A pooled analysis from the international lung cancer consortium and the SYNERGY study
G. Fehringer, DR. Brenner, ZF. Zhang, YA. Lee, K. Matsuo, H. Ito, Q. Lan, P. Vineis, M. Johansson, K. Overvad, E. Riboli, A. Trichopoulou, C. Sacerdote, I. Stucker, P. Boffetta, P. Brennan, DC. Christiani, YC. Hong, MT. Landi, H. Morgenstern, AG....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
PubMed
28120396
DOI
10.1002/ijc.30618
Knihovny.cz E-zdroje
- MeSH
- alkoholické nápoje škodlivé účinky MeSH
- kohortové studie MeSH
- kouření škodlivé účinky MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory plic epidemiologie patologie MeSH
- pití alkoholu škodlivé účinky MeSH
- rizikové faktory MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Asie epidemiologie MeSH
- Evropa epidemiologie MeSH
- Severní Amerika epidemiologie MeSH
It is not clear whether alcohol consumption is associated with lung cancer risk. The relationship is likely confounded by smoking, complicating the interpretation of previous studies. We examined the association of alcohol consumption and lung cancer risk in a large pooled international sample, minimizing potential confounding of tobacco consumption by restricting analyses to never smokers. Our study included 22 case-control and cohort studies with a total of 2548 never-smoking lung cancer patients and 9362 never-smoking controls from North America, Europe and Asia within the International Lung Cancer Consortium (ILCCO) and SYNERGY Consortium. Alcohol consumption was categorized into amounts consumed (grams per day) and also modelled as a continuous variable using restricted cubic splines for potential non-linearity. Analyses by histologic sub-type were included. Associations by type of alcohol consumed (wine, beer and liquor) were also investigated. Alcohol consumption was inversely associated with lung cancer risk with evidence most strongly supporting lower risk for light and moderate drinkers relative to non-drinkers (>0-4.9 g per day: OR = 0.80, 95% CI = 0.70-0.90; 5-9.9 g per day: OR = 0.82, 95% CI = 0.69-0.99; 10-19.9 g per day: OR = 0.79, 95% CI = 0.65-0.96). Inverse associations were found for consumption of wine and liquor, but not beer. The results indicate that alcohol consumption is inversely associated with lung cancer risk, particularly among subjects with low to moderate consumption levels, and among wine and liquor drinkers, but not beer drinkers. Although our results should have no relevant bias from the confounding effect of smoking we cannot preclude that confounding by other factors contributed to the observed associations. Confounding in relation to the non-drinker reference category may be of particular importance.
College of Public Health The Ohio State University Columbus OH
Department of Environmental Epidemiology INSERM Villejuif U170 France
Department of Epidemiology and Biostatistics Imperial College London United Kingdom
Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York NY
Department of Epidemiology School of Public Health UCLA Los Angeles CA
Department of Family and Preventive Medicine School of Medicine University of Utah Salt Lake City UT
Department of Preventive Medicine Seoul National University College of Medicine Seoul Korea
Department of Public Health Section for Epidemiology Aarhus University Denmark
Department of Surgery Memorial Sloan Kettering Cancer Center New York NY
Division Epidemiology and Prevention Aichi Cancer Center Research Institute Nagoya Japan
Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD
Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya Japan
Harvard School of Public Health Massachusetts General Hospital Harvard Medical School Boston MA
International Agency for Research on Cancer Lyon France
IUOPA University Institute of Oncology University of Oviedo and CIBERESP Spain
Karmanos Cancer Institute Wayne State University Detroit MI
Laboratory of Human Carcinogenesis Center for Cancer Research National Cancer Institute Bethesda MD
Lunenfeld Tanenbaum Research Institute Sinai Health System Toronto Canada
Masaryk Memorial Cancer Institute Brno Czech Republic
Mount Sinai School of Medicine The Tisch Cancer Institute New York NY
National Institute of Environmental Health Budapest Hungary
National Institute of Public Health Bucharest Romania
Norris Cotton Cancer Center Geisel School of Medicine Dartmouth College Lebanon USA
Palacky University Olomouc Czech Republic
Public Health Ontario Toronto Canada
Specialized Institute of Hygiene and Epidemiology Banská Bystrica Slovakia
The Nofer Institute of Occupational Medicine Lodz Poland
University of Hawaii Cancer Center Honolulu Hawaii
University of Montreal Hospital Research Center and School of Public Health Montreal Canada
Citace poskytuje Crossref.org
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