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Treponema pallidum, the syphilis spirochete: making a living as a stealth pathogen
JD. Radolf, RK. Deka, A. Anand, D. Šmajs, MV. Norgard, XF. Yang,
Language English Country England, Great Britain
Document type Journal Article, Review
NLK
ProQuest Central
from 2003-10-01 to 1 year ago
Nursing & Allied Health Database (ProQuest)
from 2003-10-01 to 1 year ago
Health & Medicine (ProQuest)
from 2003-10-01 to 1 year ago
Public Health Database (ProQuest)
from 2003-10-01 to 2017-12-31
- MeSH
- Bacterial Proteins genetics immunology MeSH
- Genomics MeSH
- Immune Evasion * MeSH
- Humans MeSH
- Bacterial Outer Membrane Proteins genetics metabolism MeSH
- Sequence Alignment MeSH
- Syphilis immunology microbiology transmission MeSH
- Toll-Like Receptor 2 immunology metabolism MeSH
- Treponema pallidum genetics immunology pathogenicity physiology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
The past two decades have seen a worldwide resurgence in infections caused by Treponema pallidum subsp. pallidum, the syphilis spirochete. The well-recognized capacity of the syphilis spirochete for early dissemination and immune evasion has earned it the designation 'the stealth pathogen'. Despite the many hurdles to studying syphilis pathogenesis, most notably the inability to culture and to genetically manipulate T. pallidum, in recent years, considerable progress has been made in elucidating the structural, physiological, and regulatory facets of T. pallidum pathogenicity. In this Review, we integrate this eclectic body of information to garner fresh insights into the highly successful parasitic lifestyles of the syphilis spirochete and related pathogenic treponemes.
Department of Biology Faculty of Medicine Masaryk University 625 00 Brno Czech Republic
Department of Medicine UConn Health 263 Farmington Avenue Farmington Connecticut 06030 3715 USA
References provided by Crossref.org
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- $a The past two decades have seen a worldwide resurgence in infections caused by Treponema pallidum subsp. pallidum, the syphilis spirochete. The well-recognized capacity of the syphilis spirochete for early dissemination and immune evasion has earned it the designation 'the stealth pathogen'. Despite the many hurdles to studying syphilis pathogenesis, most notably the inability to culture and to genetically manipulate T. pallidum, in recent years, considerable progress has been made in elucidating the structural, physiological, and regulatory facets of T. pallidum pathogenicity. In this Review, we integrate this eclectic body of information to garner fresh insights into the highly successful parasitic lifestyles of the syphilis spirochete and related pathogenic treponemes.
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