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Mitochondrial adaptations in aged skeletal muscle: effect of exercise training
M. M. Ziaaldini, S. R. Hosseini, M. Fathi
Language English Country Czech Republic
Document type Journal Article, Review
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- MeSH
- Exercise physiology MeSH
- Physical Endurance physiology MeSH
- Adaptation, Physiological physiology MeSH
- Muscle, Skeletal metabolism MeSH
- Humans MeSH
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha metabolism MeSH
- Aging metabolism MeSH
- Mitochondria, Muscle metabolism MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
The aging process is associated with a decline in mitochondrial functions. Mitochondria dysfunction is involved in initiation and progression of many health problems including neuromuscular, metabolic and cardiovascular diseases. It is well known that endurance exercise improves mitochondrial function, especially in the elderly. However, recent studies have demonstrated that resistance training lead also to substantial increases in mitochondrial function in skeletal muscle. A comprehensive understanding of the cellular mechanisms involved in the skeletal muscle mitochondrial adaptations to exercise training in healthy elderly subjects, can help practitioners to design and prescribe more effective exercise trainings.
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