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HLö - a review of acetylcholinesterase reactivator against organophosphorous intoxication
Miroslav Psotka, David Malinak, Lukas Gorecki, Thuy Duong Hguyen, Ondrej Soukup, Daniel Jun, Kamil Kuca, Kamil Musilek, Jan Korabecny
Vojenské zdravotnické listy.
2017 ;
86 (2) :
70-83.
Jazyk angličtina Země Česko
Typ dokumentu práce podpořená grantem, přehledy
Perzistentní odkaz
https://www.medvik.cz/link/bmc17026667
- Klíčová slova
- Hlo-t,
- MeSH
- acetylcholinesterasa fyziologie chemie MeSH
- chemické bojové látky otrava MeSH
- cholinesterasové inhibitory farmakologie terapeutické užití MeSH
- LD50 MeSH
- lidé MeSH
- nervová bojová látka otrava MeSH
- organofosforové sloučeniny MeSH
- otrava organofosfáty * farmakoterapie MeSH
- oximy MeSH
- pesticidy otrava MeSH
- pyridinové sloučeniny * farmakokinetika farmakologie chemická syntéza chemie terapeutické užití MeSH
- reaktivátory cholinesterázy * farmakokinetika farmakologie chemická syntéza chemie terapeutické užití MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- práce podpořená grantem MeSH
- přehledy MeSH
The treatment of organophosphate (OP) poisoning consists of the administration of a parasympatholytic agent, an anticonvulsant and an acetylcholinesterase (AChE) reactivator. Since there is no broad AChE reactivator available, a post-treatment strategy currently exploits administration of different types of oximes depending on the exposure of OP. In this contribution, we summarize all the available data about AChE reactivator HLö-7 including its synthesis, physico-chemical properties, pharmacokinetic and pharmacodynamics profile, and its efficacy in vitro and in vitro.
Bibliografie atd.
Literatura
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