-
Something wrong with this record ?
HLö - a review of acetylcholinesterase reactivator against organophosphorous intoxication
Miroslav Psotka, David Malinak, Lukas Gorecki, Thuy Duong Hguyen, Ondrej Soukup, Daniel Jun, Kamil Kuca, Kamil Musilek, Jan Korabecny
Vojenské zdravotnické listy.
2017 ;
86 (2) :
70-83.
Language English Country Czech Republic
Document type Research Support, Non-U.S. Gov't, Review
Persistent link
https://www.medvik.cz/link/bmc17026667
- Keywords
- Hlo-t,
- MeSH
- Acetylcholinesterase physiology chemistry MeSH
- Chemical Warfare Agents poisoning MeSH
- Cholinesterase Inhibitors pharmacology therapeutic use MeSH
- Lethal Dose 50 MeSH
- Humans MeSH
- Nerve Agents poisoning MeSH
- Organophosphorus Compounds MeSH
- Organophosphate Poisoning * drug therapy MeSH
- Oximes MeSH
- Pesticides poisoning MeSH
- Pyridinium Compounds * pharmacokinetics pharmacology chemical synthesis chemistry therapeutic use MeSH
- Cholinesterase Reactivators * pharmacokinetics pharmacology chemical synthesis chemistry therapeutic use MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
The treatment of organophosphate (OP) poisoning consists of the administration of a parasympatholytic agent, an anticonvulsant and an acetylcholinesterase (AChE) reactivator. Since there is no broad AChE reactivator available, a post-treatment strategy currently exploits administration of different types of oximes depending on the exposure of OP. In this contribution, we summarize all the available data about AChE reactivator HLö-7 including its synthesis, physico-chemical properties, pharmacokinetic and pharmacodynamics profile, and its efficacy in vitro and in vitro.
Bibliography, etc.
Literatura
- 000
- 00000naa a2200000 a 4500
- 001
- bmc17026667
- 003
- CZ-PrNML
- 005
- 20221101094823.0
- 007
- ta
- 008
- 170901s2017 xr f 000 0|eng||
- 009
- AR
- 024 7_
- $2 doi $a 10.31482/mmsl.2017.011
- 040 __
- $a ABA008 $d ABA008 $e AACR2 $b cze
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Psotka, Miroslav $u Biomedical Research Centre, University Hospital Hradec Kralove, Czech Republic $7 xx0277934
- 245 10
- $a HLö - a review of acetylcholinesterase reactivator against organophosphorous intoxication / $c Miroslav Psotka, David Malinak, Lukas Gorecki, Thuy Duong Hguyen, Ondrej Soukup, Daniel Jun, Kamil Kuca, Kamil Musilek, Jan Korabecny
- 504 __
- $a Literatura
- 520 9_
- $a The treatment of organophosphate (OP) poisoning consists of the administration of a parasympatholytic agent, an anticonvulsant and an acetylcholinesterase (AChE) reactivator. Since there is no broad AChE reactivator available, a post-treatment strategy currently exploits administration of different types of oximes depending on the exposure of OP. In this contribution, we summarize all the available data about AChE reactivator HLö-7 including its synthesis, physico-chemical properties, pharmacokinetic and pharmacodynamics profile, and its efficacy in vitro and in vitro.
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a LD50 $7 D007928
- 650 _2
- $a chemické bojové látky $x otrava $7 D002619
- 650 _2
- $a nervová bojová látka $x otrava $7 D000067397
- 650 _2
- $a pesticidy $x otrava $7 D010575
- 650 _2
- $a cholinesterasové inhibitory $x farmakologie $x terapeutické užití $7 D002800
- 650 12
- $a otrava organofosfáty $x farmakoterapie $7 D062025
- 650 12
- $a reaktivátory cholinesterázy $x farmakokinetika $x farmakologie $x chemická syntéza $x chemie $x terapeutické užití $7 D002801
- 650 12
- $a pyridinové sloučeniny $x farmakokinetika $x farmakologie $x chemická syntéza $x chemie $x terapeutické užití $7 D011726
- 650 _2
- $a acetylcholinesterasa $x fyziologie $x chemie $7 D000110
- 650 _2
- $a oximy $7 D010091
- 650 _2
- $a organofosforové sloučeniny $7 D009943
- 653 00
- $a Hlo-t
- 655 _2
- $a práce podpořená grantem $7 D013485
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Maliňák, Dávid $7 _AN085382 $u Biomedical Research Centre, University Hospital Hradec Kralove, Czech Republic
- 700 1_
- $a Gorecki, Lukas $u Biomedical Research Centre, University Hospital Hradec Kralove, Czech Republic; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic
- 700 1_
- $a Nguyen, Thuy Duong
- 700 1_
- $a Soukup, Ondřej $7 xx0253350 $u Biomedical Research Centre, University Hospital Hradec Kralove, Czech Republic; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic
- 700 1_
- $a Jun, Daniel, $d 1976- $7 xx0040498 $u Biomedical Research Centre, University Hospital Hradec Kralove, Czech Republic; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic
- 700 1_
- $a Kuča, Kamil, $d 1978- $7 xx0041831 $u Biomedical Research Centre, University Hospital Hradec Kralove, Czech Republic
- 700 1_
- $a Musílek, Kamil, $d 1980- $7 xx0135628 $u Biomedical Research Centre, University Hospital Hradec Kralove, Czech Republic; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic
- 700 1_
- $a Korabecny, Jan $u Biomedical Research Centre, University Hospital Hradec Kralove, Czech Republic; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic
- 773 0_
- $t Vojenské zdravotnické listy $x 0372-7025 $g Roč. 86, č. 2 (2017), s. 70-83 $w MED00011116
- 856 41
- $u http://www.mmsl.cz/archive $y domovská stránka časopisu
- 910 __
- $a ABA008 $b A 3 $c 1073 $y 4 $z 0
- 990 __
- $a 20170901133637 $b ABA008
- 991 __
- $a 20221101094820 $b ABA008
- 999 __
- $a ok $b bmc $g 1245541 $s 987641
- BAS __
- $a 3
- BMC __
- $a 2017 $b 86 $c 2 $d 70-83 $i 0372-7025 $m Vojenské zdravotnické listy $x MED00011116
- LZP __
- $c NLK188 $d 20180110 $a NLK 2017-32/dk
