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Cytomorphology review of 100 newly diagnosed lower-risk MDS patients in the European LeukemiaNet MDS (EUMDS) registry reveals a high inter-observer concordance
L. de Swart, A. Smith, M. MacKenzie, A. Symeonidis, J. Neukirchen, D. Mikulenková, T. Vallespí, G. Zini, M. Paszkowska-Kowalewska, A. Kruger, L. Saft, P. Fenaux, D. Bowen, E. Hellström-Lindberg, J. Čermák, R. Stauder, A. Tatic, MS. Holm, L....
Language English Country Germany
Document type Journal Article
NLK
ProQuest Central
from 1997-03-01
Medline Complete (EBSCOhost)
from 2000-01-01 to 1 year ago
Nursing & Allied Health Database (ProQuest)
from 1997-03-01
Health & Medicine (ProQuest)
from 1997-03-01
Springer Nature OA/Free Journals
from 1955-03-01
- MeSH
- Cytodiagnosis methods standards MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Myelodysplastic Syndromes blood diagnosis MeSH
- Observer Variation * MeSH
- Registries statistics & numerical data MeSH
- Reproducibility of Results MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Sensitivity and Specificity MeSH
- Bone Marrow Examination methods standards MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
The European LeukemiaNet MDS (EUMDS) registry is collecting data of myelodysplastic syndrome (MDS) patients belonging to the IPSS low or intermediate-1 category, newly diagnosed by local cytologists. The diagnosis of MDS can be challenging, and some data report inter-observer variability with regard to the assessment of the MDS subtype. In order to ensure that correct diagnoses were made by the participating centres, blood and bone marrow slides of 10% of the first 1000 patients were reviewed by an 11-person panel of cytomorphologists. All slides were rated by at least 3 panel members (median 8 panel members; range 3-9). Marrow slides from 98 out of 105 patients were of good quality and therefore could be rated properly according to the WHO 2001 classification, including assessment of dysplastic lineages. The agreement between the reviewers whether the diagnosis was MDS or non-MDS was strong with an intra-class correlation coefficient (ICC) of 0.85. Six cases were detected not to fit the entry criteria of the registry, because they were diagnosed uniformly as CMML or AML by the panel members. The agreement by WHO 2001 classification was strong as well (ICC = 0.83). The concordance of the assessment of dysplastic lineages was substantial for megakaryopoiesis and myelopoiesis and moderate for erythropoiesis. Our data show that in general, the inter-observer agreement was high and a very low percentage of misdiagnosed cases had been entered into the EUMDS registry. Further studies including histomorphology are warranted.
Centre of Haematology and Bone Marrow Transplantation Fundeni Clinical Institute Bucharest Romania
Department of Haematology Aarhus University Hospital Aarhus Denmark
Department of Haematology Oncology and Internal Medicine Warszawa Medical University Warszawa Poland
Department of Haematology Radboud University Medical Centre Nijmegen The Netherlands
Department of Haematology Royal Cornwall Hospital Truro UK
Department of Internal Medicine 5 Innsbruck Medical University Innsbruck Austria
Department of Medicine Division of Haematology Karolinska Institutet Stockholm Sweden
Department of Medicine Division of Haematology University of Patras Medical School Patras Greece
Epidemiology and Cancer Statistics Group Department of Health Sciences University of York York UK
Haematology Institute Catholic University of Sacred Heart Rome Italy
St James's Institute of Oncology Leeds Teaching Hospitals Leeds UK
References provided by Crossref.org
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