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Asymmetric Localization and Distribution of Factors Determining Cell Fate During Early Development of Xenopus laevis
R. Sindelka, M. Sidova, P. Abaffy, M. Kubista,
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
- MeSH
- asymetrické buněčné dělení fyziologie MeSH
- proteiny Xenopus metabolismus MeSH
- rozvržení tělního plánu fyziologie MeSH
- Xenopus laevis embryologie fyziologie MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Asymmetric division is a property of eukaryotic cells that is fundamental to the formation of higher life forms. Despite its importance, the mechanism behind it remains elusive. Asymmetry in the cell is induced by polarization of cell fate determinants that become unevenly distributed among progeny cells. So far dozens of determinants have been identified. Xenopus laevis is an ideal system to study asymmetric cell division during early development, because of the huge size of its oocytes and early-stage blastomeres. Here, we present the current knowledge about localization and distribution of cell fate determinants along the three body axes: animal-vegetal, dorsal-ventral, and left-right. Uneven distribution of cell fate determinants during early development specifies the formation of the embryonic body plan.
Citace poskytuje Crossref.org
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- $a Asymmetric division is a property of eukaryotic cells that is fundamental to the formation of higher life forms. Despite its importance, the mechanism behind it remains elusive. Asymmetry in the cell is induced by polarization of cell fate determinants that become unevenly distributed among progeny cells. So far dozens of determinants have been identified. Xenopus laevis is an ideal system to study asymmetric cell division during early development, because of the huge size of its oocytes and early-stage blastomeres. Here, we present the current knowledge about localization and distribution of cell fate determinants along the three body axes: animal-vegetal, dorsal-ventral, and left-right. Uneven distribution of cell fate determinants during early development specifies the formation of the embryonic body plan.
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- $a Sidova, Monika $u Laboratory of Gene Expression, Institute of Biotechnology, Academy of Sciences of the Czech Republic-Biocev, Prumyslova 595, 252 50, Vestec, Czech Republic.
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- $a Kubista, Mikael $u Laboratory of Gene Expression, Institute of Biotechnology, Academy of Sciences of the Czech Republic-Biocev, Prumyslova 595, 252 50, Vestec, Czech Republic. mikael.kubista@tataa.com. TATAA Biocenter AB, Odinsgatan 28, 411 03, Göteborg, Sweden. mikael.kubista@tataa.com.
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