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Comparison of imipenem and meropenem antibiotics for the MALDI-TOF MS detection of carbapenemase activity
V. Rotova, CC. Papagiannitsis, A. Skalova, K. Chudejova, J. Hrabak,
Journal of microbiological methods.
2017 ;
137 (-) :
30-33.
[pub] 20170405
Language English Country Netherlands
Document type Comparative Study, Journal Article
Persistent link
https://www.medvik.cz/link/bmc17030894
- MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Bacterial Proteins analysis metabolism MeSH
- Bacteriological Techniques methods MeSH
- beta-Lactamases analysis metabolism MeSH
- Enterobacteriaceae drug effects enzymology MeSH
- Imipenem pharmacology MeSH
- Carbapenems pharmacology MeSH
- Microbial Sensitivity Tests MeSH
- Pseudomonas aeruginosa drug effects enzymology MeSH
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization methods MeSH
- Thienamycins pharmacokinetics MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
A comparison of carbapenem molecules for the detection of carbapenemase-producing bacteria by MALDI-TOF MS showed that imipenem exhibited higher sensitivity (97%) and specificity (100%) scores for Pseudomonas aeruginosa than meropenem. However, meropenem was more efficient (98% sensitivity and 100% specificity) against Enterobacteriaceae.
References provided by Crossref.org
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