-
Something wrong with this record ?
Long-Term Cognitive Decline in Dementia with Lewy Bodies in a Large Multicenter, International Cohort
MG. Kramberger, B. Auestad, S. Garcia-Ptacek, C. Abdelnour, JG. Olmo, Z. Walker, AW. Lemstra, E. Londos, F. Blanc, L. Bonanni, I. McKeith, B. Winblad, FJ. de Jong, F. Nobili, E. Stefanova, M. Petrova, C. Falup-Pecurariu, I. Rektorova, S....
Language English Country Netherlands
Document type Journal Article, Multicenter Study
PubMed
28304294
DOI
10.3233/jad-161109
Knihovny.cz E-resources
- MeSH
- Analysis of Variance MeSH
- Lewy Body Disease complications diagnosis MeSH
- Cognition Disorders diagnosis etiology MeSH
- Cohort Studies MeSH
- Middle Aged MeSH
- Humans MeSH
- International Cooperation MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Mental Status Schedule MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
BACKGROUND/OBJECTIVE: The aim of this study was to describe the rate and clinical predictors of cognitive decline in dementia with Lewy bodies (DLB), and compare the findings with Alzheimer's disease (AD) and Parkinson's disease dementia (PDD) patients. METHODS: Longitudinal scores for the Mini-Mental State Examination (MMSE) in 1,290 patients (835 DLB, 198 PDD, and 257 AD) were available from 18 centers with up to three years longitudinal data. Linear mixed effects analyses with appropriate covariates were used to model MMSE decline over time. Several subgroup analyses were performed, defined by anti-dementia medication use, baseline MMSE score, and DLB core features. RESULTS: The mean annual decline in MMSE score was 2.1 points in DLB, compared to 1.6 in AD (p = 0.07 compared to DLB) and 1.8 in PDD (p = 0.19). Rates of decline were significantly higher in DLB compared to AD and PDD when baseline MMSE score was included as a covariate, and when only those DLB patients with an abnormal dopamine transporter SPECT scan were included. Decline was not predicted by sex, baseline MMSE score, or presence of specific DLB core features. CONCLUSIONS: The average annual decline in MMSE score in DLB is approximately two points. Although in the overall analyses there were no differences in the rate of decline between the three neurodegenerative disorders, there were indications of a more rapid decline in DLB than in AD and PDD. Further studies are needed to understand the predictors and mechanisms of cognitive decline in DLB.
3rd Department of Neurology Medical School Aristotle University of Thessaloniki Greece
Clinical Memory Research Unit Department of Clinical Sciences Lund University Malmö Sweden
Clinical Neurology Department of Neuroscience University of Genoa Italy
Department of Neurology and Alzheimer Centre VU University Medical Centre Amsterdam The Netherlands
Department of Psychiatry University of Cambridge School of Clinical Medicine Cambridge UK
Erasmus MC University Medical Center Rotterdam The Netherlands
Fundació ACE Institut Català de Neurociències Aplicades Barcelona Spain
Girona Biomedical Research Institute Girona Spain
Institute of Neurology CCS School of Medicine University of Belgrade Belgrade Serbia
University Hospital Alexandrovska Department of Neurology Sofia Bulgaria
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc17030955
- 003
- CZ-PrNML
- 005
- 20181114065522.0
- 007
- ta
- 008
- 171025s2017 ne f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.3233/JAD-161109 $2 doi
- 035 __
- $a (PubMed)28304294
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ne
- 100 1_
- $a Kramberger, Milica G $u Department of Neurology, University Medical Centre, Ljubljana, Slovenia. Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.
- 245 10
- $a Long-Term Cognitive Decline in Dementia with Lewy Bodies in a Large Multicenter, International Cohort / $c MG. Kramberger, B. Auestad, S. Garcia-Ptacek, C. Abdelnour, JG. Olmo, Z. Walker, AW. Lemstra, E. Londos, F. Blanc, L. Bonanni, I. McKeith, B. Winblad, FJ. de Jong, F. Nobili, E. Stefanova, M. Petrova, C. Falup-Pecurariu, I. Rektorova, S. Bostantjopoulou, R. Biundo, D. Weintraub, D. Aarsland, . ,
- 520 9_
- $a BACKGROUND/OBJECTIVE: The aim of this study was to describe the rate and clinical predictors of cognitive decline in dementia with Lewy bodies (DLB), and compare the findings with Alzheimer's disease (AD) and Parkinson's disease dementia (PDD) patients. METHODS: Longitudinal scores for the Mini-Mental State Examination (MMSE) in 1,290 patients (835 DLB, 198 PDD, and 257 AD) were available from 18 centers with up to three years longitudinal data. Linear mixed effects analyses with appropriate covariates were used to model MMSE decline over time. Several subgroup analyses were performed, defined by anti-dementia medication use, baseline MMSE score, and DLB core features. RESULTS: The mean annual decline in MMSE score was 2.1 points in DLB, compared to 1.6 in AD (p = 0.07 compared to DLB) and 1.8 in PDD (p = 0.19). Rates of decline were significantly higher in DLB compared to AD and PDD when baseline MMSE score was included as a covariate, and when only those DLB patients with an abnormal dopamine transporter SPECT scan were included. Decline was not predicted by sex, baseline MMSE score, or presence of specific DLB core features. CONCLUSIONS: The average annual decline in MMSE score in DLB is approximately two points. Although in the overall analyses there were no differences in the rate of decline between the three neurodegenerative disorders, there were indications of a more rapid decline in DLB than in AD and PDD. Further studies are needed to understand the predictors and mechanisms of cognitive decline in DLB.
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 _2
- $a analýza rozptylu $7 D000704
- 650 _2
- $a kognitivní poruchy $x diagnóza $x etiologie $7 D003072
- 650 _2
- $a kohortové studie $7 D015331
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mezinárodní spolupráce $7 D007391
- 650 _2
- $a demence s Lewyho tělísky $x komplikace $x diagnóza $7 D020961
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a záznam o duševním stavu $7 D008609
- 650 _2
- $a lidé středního věku $7 D008875
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a multicentrická studie $7 D016448
- 700 1_
- $a Auestad, Bjørn $u Research Department, Stavanger University Hospital and Department of Mathematics and Natural Sciences, The University of Stavanger, Stavanger, Norway. $7 gn_A_00009993
- 700 1_
- $a Garcia-Ptacek, Sara $u Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden. Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.
- 700 1_
- $a Abdelnour, Carla $u Fundació ACE Institut Català de Neurociències Aplicades, Barcelona, Spain. $7 gn_A_00000362
- 700 1_
- $a Olmo, Josep Garre $u Girona Biomedical Research Institute, Girona, Spain.
- 700 1_
- $a Walker, Zuzana $u Division of Psychiatry, University College London and North Essex Partnership University NHS Foundation Trust, UK.
- 700 1_
- $a Lemstra, Afina W $u Department of Neurology and Alzheimer Centre, VU University Medical Centre, Amsterdam, The Netherlands.
- 700 1_
- $a Londos, Elisabet $u Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.
- 700 1_
- $a Blanc, Frederic $u Service of Neurology and Geriatrics, University Hospital of Strasbourg and Icube laboratory, University of Strasbourg, France.
- 700 1_
- $a Bonanni, Laura $u Clinical Memory Research Unit, Department of Clinical Sciences, Department of Neuroscience and Imaging and Aging Research Centre, G. d'Annunzio University, Chieti, Italy.
- 700 1_
- $a McKeith, I. G. $u Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK. $7 xx0229366
- 700 1_
- $a Winblad, Bengt $u Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.
- 700 1_
- $a de Jong, Frank Jan $u Erasmus MC - University Medical Center, Rotterdam, The Netherlands.
- 700 1_
- $a Nobili, Flavio $u Clinical Neurology, Department of Neuroscience (DINOGMI), University of Genoa, Italy.
- 700 1_
- $a Stefanova, Elka $u Institute of Neurology CCS, School of Medicine, University of Belgrade, Belgrade, Serbia.
- 700 1_
- $a Petrova, Maria $u University Hospital "Alexandrovska", Department of Neurology, Sofia, Bulgaria.
- 700 1_
- $a Falup-Pecurariu, Cristian $u Department of Neurology, County Emergency Clinic Hospital, Faculty of Medicine, Transilvania University, Brasov, Romania.
- 700 1_
- $a Rektorova, Irena $u Brain and Mind Research Program, Central European Institute of Technology, Central European Institute of Technology Masaryk University, Masaryk University, Brno, Czech Republic.
- 700 1_
- $a Bostantjopoulou, Sevasti $u 3rd Department of Neurology, Medical School, Aristotle University of Thessaloniki, Greece.
- 700 1_
- $a Biundo, Roberta $u Center for Parkinson's disease and Movement Disorder "Fondazione Ospedale San Camillo" - Istituto di Ricovero e Cura a Carattere Scientifico, Venice-Lido, Italy.
- 700 1_
- $a Weintraub, Daniel $u Departments of Psychiatry and Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
- 700 1_
- $a Aarsland, Dag $u Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden. Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK. Center for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway. $7 gn_A_00000109
- 700 1_
- $a ,
- 773 0_
- $w MED00006350 $t Journal of Alzheimer's disease JAD $x 1875-8908 $g Roč. 57, č. 3 (2017), s. 787-795
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/28304294 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20171025 $b ABA008
- 991 __
- $a 20181114065608 $b ABA008
- 999 __
- $a ok $b bmc $g 1254548 $s 991982
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2017 $b 57 $c 3 $d 787-795 $i 1875-8908 $m Journal of Alzheimer's disease $n J Alzheimers Dis $x MED00006350
- LZP __
- $a Pubmed-20171025
