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Sex differences in leptin modulate ventilation in heart failure
I. Cundrle, VK. Somers, P. Singh, BD. Johnson, CG. Scott, LJ. Olson,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, pozorovací studie
- MeSH
- biologické markery krev MeSH
- cvičení fyziologie MeSH
- funkce levé komory srdeční fyziologie MeSH
- leptin krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- plicní ventilace fyziologie MeSH
- prospektivní studie MeSH
- senioři MeSH
- sexuální faktory MeSH
- spotřeba kyslíku MeSH
- srdeční selhání krev patofyziologie MeSH
- zátěžový test metody MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
BACKGROUND: Leptin modulates ventilation and circulating levels are higher in normal women than men. OBJECTIVES: The aim of this study was to compare exercise ventilation and gas exchange in men and women with heart failure (HF) and their relation to circulating leptin concentration. METHODS: Consecutive HF patients were studied by cardiopulmonary exercise testing and assay of circulating leptin concentration. RESULTS: Fifty-seven men and 20 women were similar with respect to age, BMI, NYHA class, left ventricular ejection fraction, and peak oxygen consumption (all p > 0.05). Leptin concentration was lower (10.3 ± 10 vs. 25.3 ± 16 ng/mL; p < 0.01) and peak exercise ventilatory efficiency (VE/VCO2) was higher (43 ± 10 vs. 36 ± 5; p < 0.01) in men. Leptin concentration was associated with peak exercise VE/VCO2 (b = -0.35; F = 5.6; p = 0.02). CONCLUSION: Men have significantly lower circulating leptin concentration and increased ventilatory drive during exercise than women with comparable HF. In men with HF, lower leptin concentration may account for an increased ventilatory drive.
Department of Biomedical Statistics and Informatics Mayo Clinic Rochester MN USA
Division of Cardiovascular Diseases Mayo Clinic Rochester MN USA
Citace poskytuje Crossref.org
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- $a BACKGROUND: Leptin modulates ventilation and circulating levels are higher in normal women than men. OBJECTIVES: The aim of this study was to compare exercise ventilation and gas exchange in men and women with heart failure (HF) and their relation to circulating leptin concentration. METHODS: Consecutive HF patients were studied by cardiopulmonary exercise testing and assay of circulating leptin concentration. RESULTS: Fifty-seven men and 20 women were similar with respect to age, BMI, NYHA class, left ventricular ejection fraction, and peak oxygen consumption (all p > 0.05). Leptin concentration was lower (10.3 ± 10 vs. 25.3 ± 16 ng/mL; p < 0.01) and peak exercise ventilatory efficiency (VE/VCO2) was higher (43 ± 10 vs. 36 ± 5; p < 0.01) in men. Leptin concentration was associated with peak exercise VE/VCO2 (b = -0.35; F = 5.6; p = 0.02). CONCLUSION: Men have significantly lower circulating leptin concentration and increased ventilatory drive during exercise than women with comparable HF. In men with HF, lower leptin concentration may account for an increased ventilatory drive.
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