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Carfilzomib, lenalidomide, and dexamethasone in patients with relapsed multiple myeloma categorised by age: secondary analysis from the phase 3 ASPIRE study
MA. Dimopoulos, AK. Stewart, T. Masszi, I. Špička, A. Oriol, R. Hájek, L. Rosiñol, D. Siegel, GG. Mihaylov, V. Goranova-Marinova, P. Rajnics, A. Suvorov, R. Niesvizky, A. Jakubowiak, J. San-Miguel, H. Ludwig, A. Palumbo, M. Obreja, S. Aggarwal, P. Moreau,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu klinické zkoušky, fáze III, časopisecké články, multicentrická studie, randomizované kontrolované studie
Odkazy
PubMed
28211560
DOI
10.1111/bjh.14549
Knihovny.cz E-zdroje
- MeSH
- dexamethason aplikace a dávkování MeSH
- dospělí MeSH
- Kaplanův-Meierův odhad MeSH
- lidé středního věku MeSH
- lidé MeSH
- mnohočetný myelom farmakoterapie MeSH
- oligopeptidy aplikace a dávkování MeSH
- protokoly antitumorózní kombinované chemoterapie terapeutické užití MeSH
- recidiva MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- thalidomid aplikace a dávkování analogy a deriváty MeSH
- věkové faktory MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky, fáze III MeSH
- multicentrická studie MeSH
- randomizované kontrolované studie MeSH
A primary analysis of the ASPIRE study found that the addition of carfilzomib to lenalidomide and dexamethasone (carfilzomib group) significantly improved progression-free survival (PFS) compared with lenalidomide and dexamethasone alone (control group) in patients with relapsed multiple myeloma (RMM). This post hoc analysis examined outcomes from ASPIRE in patients categorised by age. In the carfilzomib group, 103/396 patients were ≥70 years old, and in the control group, 115/396 patients were ≥70 years old. Median PFS for patients <70 years old was 28·6 months for the carfilzomib group versus 17·6 months for the control group [hazard ratio (HR), 0·701]. Median PFS for patients ≥70 years old was 23·8 months for the carfilzomib group versus 16·0 months for the control group (HR, 0·753). For patients <70 years the overall response rate (ORR) was 86·0% (carfilzomib group) and 66·9% (control group); for patients ≥70 years old the ORR was 90·3% (carfilzomib group) and 66·1% (control group). Within the carfilzomib group, grade ≥3 cardiovascular adverse events occurred more frequently among patients ≥70 years old compared with patients <70 years old. Carfilzomib-lenalidomide-dexamethasone has a favourable benefit-risk profile for patients with RMM, including elderly patients ≥70 years old. TRIAL REGISTRATION: clinicaltrials.gov identifier: NCT01080391.
1st Faculty of Medicine Charles University Prague Prague Czech Republic
Clinica Universidad de Navarra CIMA IDISNA Pamplona Spain
Department of Haematology Mór Kaposi Teaching Hospital Kaposvár Hungary
Haematological Department 1st Republican Clinical Hospital of Udmurtia Izhevsk Russia
Haematology Clinic University Multiprofile Hospital for Active Treatment Plovdiv Bulgaria
Hospital Clínic de Barcelona Barcelona Spain
Institut Català d'Oncologia Hospital Germans Trias i Pujol Barcelona Spain
John Theurer Cancer Center at Hackensack University Hackensack NJ USA
National and Kapodistrian University of Athens Athens Greece
Onyx Pharmaceuticals Inc an Amgen subsidiary South San Francisco CA USA
Queen Joanna University Hospital Sofia Bulgaria
University Hospital Ostrava and Faculty of Medicine University of Ostrava Ostrava Czech Republic
University of Chicago Medical Center Chicago IL USA
University of Nantes Nantes France
University of Torino Torino Italy
Weill Cornell Medical College New York NY USA
Wilhelminen Cancer Research Institute Wilhelminenspital Vienna Austria
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