Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer

G. Plitas, C. Konopacki, K. Wu, PD. Bos, M. Morrow, EV. Putintseva, DM. Chudakov, AY. Rudensky,

. 2016 ; 45 (5) : 1122-1134.

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc17031290

Regulatory T (Treg) cells reside in lymphoid organs and barrier tissues where they control different types of inflammatory responses. Treg cells are also found in human cancers, and studies in animal models suggest that they contribute to cancer progression. However, properties of human intratumoral Treg cells and those present in corresponding normal tissue remain largely unknown. Here, we analyzed features of Treg cells in untreated human breast carcinomas, normal mammary gland, and peripheral blood. Tumor-resident Treg cells were potently suppressive and their gene-expression pattern resembled that of normal breast tissue, but not of activated peripheral blood Treg cells. Nevertheless, a number of cytokine and chemokine receptor genes, most notably CCR8, were upregulated in tumor-resident Treg cells in comparison to normal tissue-resident ones. Our studies suggest that targeting CCR8 for the depletion of tumor-resident Treg cells might represent a promising immunotherapeutic approach for the treatment of breast cancer.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17031290
003      
CZ-PrNML
005      
20171103113003.0
007      
ta
008      
171025s2016 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.immuni.2016.10.032 $2 doi
035    __
$a (PubMed)27851913
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Plitas, George $u Howard Hughes Medical Institute, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunology Program, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Ludwig Center at Memorial Sloan Kettering Cancer Center, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
245    10
$a Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer / $c G. Plitas, C. Konopacki, K. Wu, PD. Bos, M. Morrow, EV. Putintseva, DM. Chudakov, AY. Rudensky,
520    9_
$a Regulatory T (Treg) cells reside in lymphoid organs and barrier tissues where they control different types of inflammatory responses. Treg cells are also found in human cancers, and studies in animal models suggest that they contribute to cancer progression. However, properties of human intratumoral Treg cells and those present in corresponding normal tissue remain largely unknown. Here, we analyzed features of Treg cells in untreated human breast carcinomas, normal mammary gland, and peripheral blood. Tumor-resident Treg cells were potently suppressive and their gene-expression pattern resembled that of normal breast tissue, but not of activated peripheral blood Treg cells. Nevertheless, a number of cytokine and chemokine receptor genes, most notably CCR8, were upregulated in tumor-resident Treg cells in comparison to normal tissue-resident ones. Our studies suggest that targeting CCR8 for the depletion of tumor-resident Treg cells might represent a promising immunotherapeutic approach for the treatment of breast cancer.
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a nádory prsu $x imunologie $7 D001943
650    _2
$a separace buněk $7 D002469
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a průtoková cytometrie $7 D005434
650    _2
$a stanovení celkové genové exprese $7 D020869
650    _2
$a lidé $7 D006801
650    _2
$a tumor infiltrující lymfocyty $7 D016246
650    _2
$a lidé středního věku $7 D008875
650    _2
$a fenotyp $7 D010641
650    _2
$a receptory CCR8 $x biosyntéza $x imunologie $7 D054401
650    _2
$a regulační T-lymfocyty $x imunologie $7 D050378
650    _2
$a transkriptom $7 D059467
650    _2
$a mladý dospělý $7 D055815
655    _2
$a časopisecké články $7 D016428
700    1_
$a Konopacki, Catherine $u Howard Hughes Medical Institute, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunology Program, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
700    1_
$a Wu, Kenmin $u Howard Hughes Medical Institute, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunology Program, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Ludwig Center at Memorial Sloan Kettering Cancer Center, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
700    1_
$a Bos, Paula D $u Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.
700    1_
$a Morrow, Monica $u Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
700    1_
$a Putintseva, Ekaterina V $u Bioinformatics and Genomics Programme, Centre for Genomic Regulation Barcelona 08003, Spain; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia.
700    1_
$a Chudakov, Dmitriy M $u Central European Institute of Technology, Brno 60177, Czech Republic; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia; Pirogov Russian National Research Medical University, Moscow 117997, Russia.
700    1_
$a Rudensky, Alexander Y $u Howard Hughes Medical Institute, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunology Program, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Ludwig Center at Memorial Sloan Kettering Cancer Center, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: rudenska@mskcc.org.
773    0_
$w MED00002186 $t Immunity $x 1097-4180 $g Roč. 45, č. 5 (2016), s. 1122-1134
856    41
$u https://pubmed.ncbi.nlm.nih.gov/27851913 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20171025 $b ABA008
991    __
$a 20171103113057 $b ABA008
999    __
$a ok $b bmc $g 1254883 $s 992317
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2016 $b 45 $c 5 $d 1122-1134 $i 1097-4180 $m Immunity $n Immunity $x MED00002186
LZP    __
$a Pubmed-20171025

Najít záznam

Citační ukazatele

Možnosti archivace