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Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer
C. Lesseur, B. Diergaarde, AF. Olshan, V. Wünsch-Filho, AR. Ness, G. Liu, M. Lacko, J. Eluf-Neto, S. Franceschi, P. Lagiou, GJ. Macfarlane, L. Richiardi, S. Boccia, J. Polesel, K. Kjaerheim, D. Zaridze, M. Johansson, AM. Menezes, MP. Curado, M....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu srovnávací studie, časopisecké články
NLK
ProQuest Central
od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
PubMed
27749845
DOI
10.1038/ng.3685
Knihovny.cz E-zdroje
- MeSH
- celogenomová asociační studie * MeSH
- genetická predispozice k nemoci * MeSH
- genetická variace genetika MeSH
- genetické markery genetika MeSH
- haplotypy genetika MeSH
- HLA antigeny MeSH
- infekce papilomavirem genetika virologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory hltanu genetika virologie MeSH
- nádory úst genetika virologie MeSH
- Papillomaviridae izolace a purifikace MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- ústa metabolismus patologie virologie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 × 10(-8)), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci-9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1*1301-HLA-DQA1*0103-HLA-DQB1*0603 (odds ratio (OR) = 0.59, P = 2.7 × 10(-9)). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 × 10(-6)) than in HPV-negative (OR = 0.75, P = 0.16) cancers.
Cancer Registry of Norway Oslo Norway
Centre for Oral Health Research Newcastle University Newcastle UK
Deparment of Molecular Medicine University of Padova Padova Italy
Department of Environmental Epidemiology Nofer Institute of Occupational Medicine Lodz Poland
Department of Gastroenterology Radboud University Nijmegen Medical Center Nijmegen the Netherlands
Department of Head and Neck Surgery Heliópolis Hospital São Paulo Brazil
Department of Medical Sciences University of Turin Turin Italy
Department of Stomatology School of Dentistry University of São Paulo São Paulo Brazil
Epidemiology International Center for Research A C Camargo Cancer Center Sao Paulo Brazil
Faculdade de Saúde Pública Universidade de São Paulo São Paulo Brazil
German Institute of Human Nutrition in Potsdam Rehbruecke Nuthetal Germany
Institut Català d'Oncologia IDIBELL CIBERESP l'Hospitalet de Llobregat Barcelona Spain
Instituto de Oncología 'Angel H Roffo' Universidad de Buenos Aires Buenos Aires Argentina
International Agency for Research on Cancer Lyon France
Leibniz Institute for Prevention Research and Epidemiology BIPS Bremen Germany
Lunenfeld Tanenbaum Research Institute Mount Sinai Hospital Toronto Ontario Canada
Maria Skłodowska Curie Memorial Cancer Centre and Institute of Oncology Warsaw Poland
National Institute of Public Health Bucharest Romania
Princess Margaret Cancer Centre Toronto Ontario Canada
Programa de Pós Graduacão em Epidemiologia Universidade Federal de Pelotas Pelotas Brazil
Regional Authority of Public Health Banská Bystrica Slovakia
School of Medicine Medical Sciences and Nutrition University of Aberdeen Aberdeen UK
School of Oral and Dental Sciences University of Bristol Bristol UK
Tisch Cancer Institute Icahn School of Medicine at Mount Sinai New York New York USA
Trinity College School of Dental Science Dublin Ireland
Unit of Cancer Epidemiology CRO Aviano National Cancer Institute Aviano Italy
Citace poskytuje Crossref.org
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- $a Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer / $c C. Lesseur, B. Diergaarde, AF. Olshan, V. Wünsch-Filho, AR. Ness, G. Liu, M. Lacko, J. Eluf-Neto, S. Franceschi, P. Lagiou, GJ. Macfarlane, L. Richiardi, S. Boccia, J. Polesel, K. Kjaerheim, D. Zaridze, M. Johansson, AM. Menezes, MP. Curado, M. Robinson, W. Ahrens, C. Canova, A. Znaor, X. Castellsagué, DI. Conway, I. Holcátová, D. Mates, M. Vilensky, CM. Healy, N. Szeszenia-Dąbrowska, E. Fabiánová, J. Lissowska, JR. Grandis, MC. Weissler, EH. Tajara, FD. Nunes, MB. de Carvalho, S. Thomas, RJ. Hung, WH. Peters, R. Herrero, G. Cadoni, HB. Bueno-de-Mesquita, A. Steffen, A. Agudo, O. Shangina, X. Xiao, V. Gaborieau, A. Chabrier, D. Anantharaman, P. Boffetta, CI. Amos, JD. McKay, P. Brennan,
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