• Je něco špatně v tomto záznamu ?

Parasite Cathepsin D-Like Peptidases and Their Relevance as Therapeutic Targets

D. Sojka, D. Hartmann, P. Bartošová-Sojková, J. Dvořák,

. 2016 ; 32 (9) : 708-23. [pub] 20160622

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc17031629

Inhibition of aspartic cathepsin D-like peptidases (APDs) has been often discussed as an antiparasite intervention strategy. APDs have been considered as virulence factors of Trypanosoma cruzi and Leishmania spp., and have been demonstrated to have important roles in protein trafficking mechanisms of apicomplexan parasites. APDs also initiate blood digestion as components of multienzyme proteolytic complexes in malaria, platyhelminths, nematodes, and ticks. Increasing DNA and RNA sequencing data indicate that parasites express multiple APD isoenzymes of various functions that can now be specifically evaluated using new functional-genomic and biochemical tools, from which we can further assess the potential of APDs as targets for novel effective intervention strategies against parasitic diseases that still pose an alarming threat to mankind.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17031629
003      
CZ-PrNML
005      
20171027103336.0
007      
ta
008      
171025s2016 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.pt.2016.05.015 $2 doi
035    __
$a (PubMed)27344362
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Sojka, Daniel $u Institute of Parasitology, Biology Centre, The Czech Academy of Sciences, Ceske Budejovice 370 05, Czech Republic. Electronic address: sojkadan@gmail.com.
245    10
$a Parasite Cathepsin D-Like Peptidases and Their Relevance as Therapeutic Targets / $c D. Sojka, D. Hartmann, P. Bartošová-Sojková, J. Dvořák,
520    9_
$a Inhibition of aspartic cathepsin D-like peptidases (APDs) has been often discussed as an antiparasite intervention strategy. APDs have been considered as virulence factors of Trypanosoma cruzi and Leishmania spp., and have been demonstrated to have important roles in protein trafficking mechanisms of apicomplexan parasites. APDs also initiate blood digestion as components of multienzyme proteolytic complexes in malaria, platyhelminths, nematodes, and ticks. Increasing DNA and RNA sequencing data indicate that parasites express multiple APD isoenzymes of various functions that can now be specifically evaluated using new functional-genomic and biochemical tools, from which we can further assess the potential of APDs as targets for novel effective intervention strategies against parasitic diseases that still pose an alarming threat to mankind.
650    _2
$a zvířata $7 D000818
650    _2
$a antiparazitární látky $x farmakologie $x terapeutické užití $7 D000977
650    12
$a lékové transportní systémy $7 D016503
650    _2
$a inhibitory enzymů $x farmakologie $7 D004791
650    _2
$a paraziti $x enzymologie $7 D010271
650    _2
$a parazitární nemoci $x farmakoterapie $x enzymologie $7 D010272
650    _2
$a proteasy $x metabolismus $7 D010447
650    _2
$a transport proteinů $x genetika $7 D021381
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Hartmann, David $u Institute of Parasitology, Biology Centre, The Czech Academy of Sciences, Ceske Budejovice 370 05, Czech Republic.
700    1_
$a Bartošová-Sojková, Pavla $u Institute of Parasitology, Biology Centre, The Czech Academy of Sciences, Ceske Budejovice 370 05, Czech Republic.
700    1_
$a Dvořák, Jan $u Institute of Molecular Genetics, The Czech Academy of Sciences, Prague 14220, Czech Republic; Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Prague 16610, Czech Republic; School of Biological Sciences, Queen's University Belfast, Belfast BT9 7BL, UK.
773    0_
$w MED00006043 $t Trends in parasitology $x 1471-5007 $g Roč. 32, č. 9 (2016), s. 708-23
856    41
$u https://pubmed.ncbi.nlm.nih.gov/27344362 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20171025 $b ABA008
991    __
$a 20171027103421 $b ABA008
999    __
$a ok $b bmc $g 1255222 $s 992656
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2016 $b 32 $c 9 $d 708-23 $e 20160622 $i 1471-5007 $m Trends in parasitology $n Trends Parasitol $x MED00006043
LZP    __
$a Pubmed-20171025

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace