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Atypical language representation in children with intractable temporal lobe epilepsy

A. Maulisova, B. Korman, G. Rey, B. Bernal, M. Duchowny, M. Niederlova, P. Krsek, V. Novak,

. 2016 ; 58 (-) : 91-6. [pub] 20160408

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc17031793

This study evaluated language organization in children with intractable epilepsy caused by temporal lobe focal cortical dysplasia (FCD) alone or dual pathology (temporal lobe FCD and hippocampal sclerosis, HS). We analyzed clinical, neurological, fMRI, neuropsychological, and histopathologic data in 46 pediatric patients with temporal lobe lesions who underwent excisional epilepsy surgery. The frequency of atypical language representation was similar in both groups, but children with dual pathology were more likely to be left-handed. Atypical receptive language cortex correlated with lower intellectual capacity, verbal abstract conceptualization, receptive language abilities, verbal working memory, and a history of status epilepticus but did not correlate with higher seizure frequency or early seizure onset. Histopathologic substrate had only a minor influence on neuropsychological status. Greater verbal comprehension deficits were noted in children with atypical receptive language representation, a risk factor for cognitive morbidity.

Citace poskytuje Crossref.org

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$a This study evaluated language organization in children with intractable epilepsy caused by temporal lobe focal cortical dysplasia (FCD) alone or dual pathology (temporal lobe FCD and hippocampal sclerosis, HS). We analyzed clinical, neurological, fMRI, neuropsychological, and histopathologic data in 46 pediatric patients with temporal lobe lesions who underwent excisional epilepsy surgery. The frequency of atypical language representation was similar in both groups, but children with dual pathology were more likely to be left-handed. Atypical receptive language cortex correlated with lower intellectual capacity, verbal abstract conceptualization, receptive language abilities, verbal working memory, and a history of status epilepticus but did not correlate with higher seizure frequency or early seizure onset. Histopathologic substrate had only a minor influence on neuropsychological status. Greater verbal comprehension deficits were noted in children with atypical receptive language representation, a risk factor for cognitive morbidity.
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$a Korman, Brandon $u Brain Institute, Nicklaus Children's Hospital, Miami, FL, United States. Electronic address: brandon.korman@mch.com.
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$a Rey, Gustavo $u Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, United States.
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$a Bernal, Byron $u Department of Radiology, Nicklaus Children's Hospital, Miami, FL, United States.
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$a Duchowny, Michael $u Brain Institute, Nicklaus Children's Hospital, Miami, FL, United States; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, United States.
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$a Niederlova, Marketa $u Charles University, Faculty of Arts, Department of Psychology, Prague, Czech Republic.
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$a Krsek, Pavel $u Charles University, 2nd Faculty of Medicine, Prague, Czech Republic; Motol University Hospital, Prague, Czech Republic.
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$a Novak, Vilem $u University of Ostrava, Faculty of Medicine, Ostrava, Czech Republic; Faculty Hospital Ostrava, Ostrava, Czech Republic.
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