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One Loop to Rule Them All: The Ping-Pong Cycle and piRNA-Guided Silencing
B. Czech, GJ. Hannon,
Language English Country England, Great Britain
Document type Journal Article, Review
- MeSH
- Argonaute Proteins genetics metabolism MeSH
- Chromosomal Proteins, Non-Histone genetics metabolism MeSH
- Drosophila melanogaster genetics metabolism MeSH
- Transcription, Genetic MeSH
- Histones genetics metabolism MeSH
- Humans MeSH
- RNA, Small Interfering genetics metabolism MeSH
- RNA, Messenger genetics metabolism MeSH
- Microtubule-Associated Proteins genetics metabolism MeSH
- Drosophila Proteins genetics metabolism MeSH
- RNA-Binding Proteins genetics metabolism MeSH
- Gene Silencing * MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
The PIWI-interacting RNA (piRNA) pathway is a conserved defense mechanism that protects the genetic information of animal germ cells from the deleterious effects of molecular parasites, such as transposons. Discovered nearly a decade ago, this small RNA silencing system comprises PIWI-clade Argonaute proteins and their associated RNA-binding partners, the piRNAs. In this review, we highlight recent work that has advanced our understanding of how piRNAs preserve genome integrity across generations. We discuss the mechanism of piRNA biogenesis, give an overview of common themes as well as differences in piRNA-mediated silencing between species, and end by highlighting known and emerging functions of piRNAs.
References provided by Crossref.org
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- $a The PIWI-interacting RNA (piRNA) pathway is a conserved defense mechanism that protects the genetic information of animal germ cells from the deleterious effects of molecular parasites, such as transposons. Discovered nearly a decade ago, this small RNA silencing system comprises PIWI-clade Argonaute proteins and their associated RNA-binding partners, the piRNAs. In this review, we highlight recent work that has advanced our understanding of how piRNAs preserve genome integrity across generations. We discuss the mechanism of piRNA biogenesis, give an overview of common themes as well as differences in piRNA-mediated silencing between species, and end by highlighting known and emerging functions of piRNAs.
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