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Whisper mutations: cryptic messages within the genetic code
R. Fåhraeus, M. Marin, V. Olivares-Illana,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, přehledy
NLK
ProQuest Central
od 2000-01-01 do Před 1 rokem
Open Access Digital Library
od 1997-01-01
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
PubMed
26657150
DOI
10.1038/onc.2015.454
Knihovny.cz E-zdroje
- MeSH
- genetický kód genetika MeSH
- kodon genetika MeSH
- lidé MeSH
- messenger RNA chemie genetika MeSH
- modely genetické MeSH
- mutace * MeSH
- otevřené čtecí rámce genetika MeSH
- proteiny chemie genetika metabolismus MeSH
- proteosyntéza genetika MeSH
- sbalování proteinů MeSH
- sbalování RNA MeSH
- stabilita RNA genetika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Recent years have seen a great expansion in our understandings of how silent mutations can drive a disease and that mRNAs are not only mere messengers between the genome and the encoded proteins but also encompass regulatory activities. This review focuses on how silent mutations within open reading frames can affect the functional properties of the encoded protein. We describe how mRNAs exert control of cell biological processes governed by the encoded proteins via translation kinetics, protein folding, mRNA stability, spatio-temporal protein expression and by direct interactions with cellular factors. These examples illustrate how additional levels of information lie within the coding sequences and that the degenerative genetic code is not redundant and have co-evolved with the encoded proteins. Hence, so called synonymous mutations are not always silent but 'whisper'.
Citace poskytuje Crossref.org
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