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Whisper mutations: cryptic messages within the genetic code
R. Fåhraeus, M. Marin, V. Olivares-Illana,
Language English Country England, Great Britain
Document type Journal Article, Review
NLK
ProQuest Central
from 2000-01-01 to 1 year ago
Open Access Digital Library
from 1997-01-01
Health & Medicine (ProQuest)
from 2000-01-01 to 1 year ago
Public Health Database (ProQuest)
from 2000-01-01 to 1 year ago
PubMed
26657150
DOI
10.1038/onc.2015.454
Knihovny.cz E-resources
- MeSH
- Genetic Code genetics MeSH
- Codon genetics MeSH
- Humans MeSH
- RNA, Messenger chemistry genetics MeSH
- Models, Genetic MeSH
- Mutation * MeSH
- Open Reading Frames genetics MeSH
- Proteins chemistry genetics metabolism MeSH
- Protein Biosynthesis genetics MeSH
- Protein Folding MeSH
- RNA Folding MeSH
- RNA Stability genetics MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Recent years have seen a great expansion in our understandings of how silent mutations can drive a disease and that mRNAs are not only mere messengers between the genome and the encoded proteins but also encompass regulatory activities. This review focuses on how silent mutations within open reading frames can affect the functional properties of the encoded protein. We describe how mRNAs exert control of cell biological processes governed by the encoded proteins via translation kinetics, protein folding, mRNA stability, spatio-temporal protein expression and by direct interactions with cellular factors. These examples illustrate how additional levels of information lie within the coding sequences and that the degenerative genetic code is not redundant and have co-evolved with the encoded proteins. Hence, so called synonymous mutations are not always silent but 'whisper'.
References provided by Crossref.org
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