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Anti-tumour necrosis factor activity in saliva of various tick species and its appearance during the feeding period
M. Rezkova, J. Kopecky
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články
NLK
Free Medical Journals
od 1966
ProQuest Central
od 2004-01-01 do Před 3 měsíci
Health & Medicine (ProQuest)
od 2004-01-01 do Před 3 měsíci
Public Health Database (ProQuest)
od 2004-01-01 do Před 3 měsíci
ROAD: Directory of Open Access Scholarly Resources
od 1982
- MeSH
- klíště * MeSH
- sliny * imunologie MeSH
- stravovací zvyklosti MeSH
- TNF-alfa * antagonisté a inhibitory MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Tumour necrosis factor (TNF) plays a central role in the inflammatory process. In the skin, it contributes to immune containment of tick-transmitted pathogens like Borrelia burgdorferi. In the saliva of some tick species, active compounds are present that inhibit detection of TNF in specific ELISA. We compared the presence of anti-TNF activity in saliva or salivary gland extract from 11 tick species from the family Ixodidae and demonstrated it in genera Ixodes Latreille, 1795 and Haemaphysalis Koch, 1844. Analysis of anti-TNF activity in Ixodes ricinus (Linnaeus, 1758) saliva during the feeding period showed that it is present in the late, rapid phase of engorgement. Significance of anti-TNF activity for tick feeding and transmission of tick-borne pathogens is discussed.
Citace poskytuje Crossref.org
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