Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Iodine Content Analysis Using Dual-Energy Computed Tomography as a Biomarker of Transitional Cell Carcinoma, an Experience with Separation of the Clotted Blood and Tumorous Tissue

H. Mirka, J. Baxa, M. Hora, O. Hes, O. Topolcan, J. Ferda,

. 2018 ; 38 (1) : 541-545.

Language English Country Greece

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc18010225

BACKGROUND/AIM: The aim of this study was to evaluate the possibility to discriminate the blood clot from tumorous tissue in the assessment of transitional cell carcinoma (TCC), when CT data are used only from single-phase dual-energy CT (DECT). MATERIALS AND METHODS: A total of 18 patients were included into the retrospective analysis of the prospectively collected data (the average age was 67.3 years, range=62-79 years, 12 males, 6 females). DECT was performed in all patients after intravenous administration of the iodinated contrast material. DECT analysis using three-material decomposition algorithm was used to discriminate blood and enhancing tumorous tissue. In all patients, TCC was detected and subsequently kidney surgery or endoscopy was performed within the next two weeks. The findings were compared with DECT results. RESULTS: In our cohort of patients we found 9 TCC of the renal pelvis or ureter and 7 TCC of the urinary bladder. The accuracy of the TCC detection was 94% (17/18). The presence of coagulated blood within the urinary collecting system together with a tumor was detected in 7 CT examinations. The blood coagulum without a confirmed malignant tumor was found in one case with false positive DECT finding. In other 6 cases bleeding was confirmed during surgery or endoscopy (accuracy 87%). CONCLUSION: The dual-energy data analysis enables discrimination of a blood clot from tumorous tissue. It helps in detection of UCC in cases when the excretion potential of the kidneys is decreased due to fulfillment of the collecting system with blood clots.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc18010225
003      
CZ-PrNML
005      
20180413150620.0
007      
ta
008      
180404s2018 gr f 000 0|eng||
009      
AR
024    7_
$a 10.21873/anticanres.12256 $2 doi
035    __
$a (PubMed)29277821
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a gr
100    1_
$a Mirka, Hynek $u Department of Imaging Methods, Medical School and Teaching Hospital Pilsen, Charles University in Prague, Pilsen, Czech Republic mirka@fnplzen.cz. Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic.
245    10
$a Iodine Content Analysis Using Dual-Energy Computed Tomography as a Biomarker of Transitional Cell Carcinoma, an Experience with Separation of the Clotted Blood and Tumorous Tissue / $c H. Mirka, J. Baxa, M. Hora, O. Hes, O. Topolcan, J. Ferda,
520    9_
$a BACKGROUND/AIM: The aim of this study was to evaluate the possibility to discriminate the blood clot from tumorous tissue in the assessment of transitional cell carcinoma (TCC), when CT data are used only from single-phase dual-energy CT (DECT). MATERIALS AND METHODS: A total of 18 patients were included into the retrospective analysis of the prospectively collected data (the average age was 67.3 years, range=62-79 years, 12 males, 6 females). DECT was performed in all patients after intravenous administration of the iodinated contrast material. DECT analysis using three-material decomposition algorithm was used to discriminate blood and enhancing tumorous tissue. In all patients, TCC was detected and subsequently kidney surgery or endoscopy was performed within the next two weeks. The findings were compared with DECT results. RESULTS: In our cohort of patients we found 9 TCC of the renal pelvis or ureter and 7 TCC of the urinary bladder. The accuracy of the TCC detection was 94% (17/18). The presence of coagulated blood within the urinary collecting system together with a tumor was detected in 7 CT examinations. The blood coagulum without a confirmed malignant tumor was found in one case with false positive DECT finding. In other 6 cases bleeding was confirmed during surgery or endoscopy (accuracy 87%). CONCLUSION: The dual-energy data analysis enables discrimination of a blood clot from tumorous tissue. It helps in detection of UCC in cases when the excretion potential of the kidneys is decreased due to fulfillment of the collecting system with blood clots.
650    _2
$a senioři $7 D000368
650    _2
$a algoritmy $7 D000465
650    _2
$a nádorové biomarkery $x analýza $7 D014408
650    _2
$a karcinom z přechodných buněk $x diagnóza $x diagnostické zobrazování $x patologie $7 D002295
650    _2
$a kontrastní látky $7 D003287
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a jod $x analýza $7 D007455
650    _2
$a ledviny $x patologie $x chirurgie $7 D007668
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a retrospektivní studie $7 D012189
650    _2
$a trombóza $x diagnóza $7 D013927
650    _2
$a počítačová rentgenová tomografie $x metody $7 D014057
650    _2
$a močový měchýř $x patologie $x chirurgie $7 D001743
655    _2
$a časopisecké články $7 D016428
700    1_
$a Baxa, Jan $u Department of Imaging Methods, Medical School and Teaching Hospital Pilsen, Charles University in Prague, Pilsen, Czech Republic.
700    1_
$a Hora, Milan $u Department of Urology, Medical School and Teaching Hospital Pilsen, Charles University in Prague, Pilsen, Czech Republic.
700    1_
$a Hes, Ondrej $u Sikl's Department of Pathology, Medical School and Teaching Hospital Pilsen, Charles University in Prague, Pilsen, Czech Republic.
700    1_
$a Topolcan, Ondrej $u Central Laboratory for Immunoanalysis, Medical School and Teaching Hospital Pilsen, Charles University in Prague, Pilsen, Czech Republic.
700    1_
$a Ferda, Jiri $u Department of Imaging Methods, Medical School and Teaching Hospital Pilsen, Charles University in Prague, Pilsen, Czech Republic.
773    0_
$w MED00000478 $t Anticancer research $x 1791-7530 $g Roč. 38, č. 1 (2018), s. 541-545
856    41
$u https://pubmed.ncbi.nlm.nih.gov/29277821 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20180404 $b ABA008
991    __
$a 20180413150713 $b ABA008
999    __
$a ok $b bmc $g 1287710 $s 1007037
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 38 $c 1 $d 541-545 $i 1791-7530 $m Anticancer research $n Anticancer Res $x MED00000478
LZP    __
$a Pubmed-20180404

Find record

Citation metrics

Archiving options