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Animal models to explore the effects of glucocorticoids on skeletal growth and structure
CL. Wood, O. Soucek, SC. Wong, F. Zaman, C. Farquharson, L. Savendahl, SF. Ahmed,
Language English Country Great Britain
Document type Journal Article, Review
PubMed
29051192
DOI
10.1530/joe-17-0361
Knihovny.cz E-resources
- MeSH
- Animals, Genetically Modified MeSH
- Glucocorticoids adverse effects MeSH
- Skeleton growth & development MeSH
- Humans MeSH
- Disease Models, Animal * MeSH
- Osteocytes drug effects MeSH
- Osteoclasts drug effects MeSH
- Osteoporosis chemically induced MeSH
- Growth Disorders chemically induced MeSH
- Bone Development drug effects MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Glucocorticoids (GCs) are effective for the treatment of many chronic conditions, but their use is associated with frequent and wide-ranging adverse effects including osteoporosis and growth retardation. The mechanisms that underlie the undesirable effects of GCs on skeletal development are unclear, and there is no proven effective treatment to combat them. Anin vivomodel that investigates the development and progression of GC-induced changes in bone is, therefore, important and a well-characterized pre-clinical model is vital for the evaluation of new interventions. Currently, there is no established animal model to investigate GC effects on skeletal development and there are pros and cons to consider with the different protocols used to induce osteoporosis and growth retardation. This review will summarize the literature and highlight the models and techniques employed in experimental studies to date.
Developmental Endocrinology Research GroupSchool of Medicine University of Glasgow Glasgow UK
Division of Developmental BiologyRoslin Institute University of Edinburgh Edinburgh UK
References provided by Crossref.org
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