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Identification of a hybrid myocardial zone in the mammalian heart after birth
X. Tian, Y. Li, L. He, H. Zhang, X. Huang, Q. Liu, W. Pu, L. Zhang, Y. Li, H. Zhao, Z. Wang, J. Zhu, Y. Nie, S. Hu, D. Sedmera, TP. Zhong, Y. Yu, L. Zhang, Y. Yan, Z. Qiao, QD. Wang, SM. Wu, WT. Pu, RH. Anderson, B. Zhou,
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc18010412
Online
Plný text
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- MeSH
- buněčný rodokmen MeSH
- kardiomyocyty metabolismus MeSH
- kardiomyopatie vrozené embryologie metabolismus MeSH
- myokard metabolismus patologie MeSH
- myši MeSH
- natriuretický peptid typu C metabolismus MeSH
- novorozená zvířata MeSH
- organogeneze MeSH
- proteinové prekurzory metabolismus MeSH
- represorové proteiny metabolismus MeSH
- srdce embryologie růst a vývoj MeSH
- srdeční komory embryologie růst a vývoj metabolismus patologie MeSH
- transkripční faktory bHLH metabolismus MeSH
- vrozené srdeční vady embryologie metabolismus MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Noncompaction cardiomyopathy is characterized by the presence of extensive trabeculations, which could lead to heart failure and malignant arrhythmias. How trabeculations resolve to form compact myocardium is poorly understood. Elucidation of this process is critical to understanding the pathophysiology of noncompaction disease. Here we use genetic lineage tracing to mark the Nppa+or Hey2+cardiomyocytes as trabecular and compact components of the ventricular wall. We find that Nppa+and Hey2+cardiomyocytes, respectively, from the endocardial and epicardial zones of the ventricular wall postnatally. Interposed between these two postnatal layers is a hybrid zone, which is composed of cells derived from both the Nppa+and Hey2+populations. Inhibition of the fetal Hey2+cell contribution to the hybrid zone results in persistence of excessive trabeculations in postnatal heart. Our findings indicate that the expansion of Hey2+fetal compact component, and its contribution to the hybrid myocardial zone, are essential for normal formation of the ventricular walls.Fetal trabecular muscles in the heart undergo a poorly described morphogenetic process that results into a solidified compact myocardium after birth. Tian et al. show that cardiomyocytes in the fetal compact layer also contribute to this process, forming a hybrid myocardial zone that is composed of cells derived from both trabecular and compact layers.
Cardiology Department Zhongshan Hospital Fudan University Shanghai 200032 China
Institute of Anatomy 1st Faculty of Medicine Charles University
Institute of Genetic Medicine Newcastle University Newcastle upon Tyne NE1 7RU UK
Institute of Physiology The Czech Academy of Sciences Prague 12800 Czech Republic
Citace poskytuje Crossref.org
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