-
Je něco špatně v tomto záznamu ?
Fine tuning of vitamin D receptor (VDR) activity by post-transcriptional and post-translational modifications
O. Zenata, R. Vrzal,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, přehledy
NLK
Free Medical Journals
od 2010
Freely Accessible Journals
od 2010
PubMed Central
od 2010
Europe PubMed Central
od 2010
Open Access Digital Library
od 2010-01-01
- MeSH
- fosforylace MeSH
- genetická transkripce MeSH
- lidé MeSH
- mikro RNA genetika MeSH
- posttranslační úpravy proteinů * MeSH
- receptory kalcitriolu genetika metabolismus MeSH
- regulace genové exprese MeSH
- sumoylace MeSH
- ubikvitinace MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Vitamin D receptor (VDR) is a member of the nuclear receptor (NR) superfamily of ligand-activated transcription factors. Activated VDR is responsible for maintaining calcium and phosphate homeostasis, and is required for proper cellular growth, cell differentiation and apoptosis. The expression of both phases I and II drug-metabolizing enzymes is also regulated by VDR, therefore it is clinically important.Post-translational modifications of NRs have been known as an important mechanism modulating the activity of NRs and their ability to drive the expression of target genes. The aim of this mini review is to summarize the current knowledge about post-transcriptional and post-translational modifications of VDR.
Department of Cell Biology and Genetics Faculty of Science Palacky University Olomouc Czech Republic
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc18010662
- 003
- CZ-PrNML
- 005
- 20180404142158.0
- 007
- ta
- 008
- 180404s2017 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.18632/oncotarget.15697 $2 doi
- 035 __
- $a (PubMed)28427151
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Zenata, Ondrej $u Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Olomouc, Czech Republic.
- 245 10
- $a Fine tuning of vitamin D receptor (VDR) activity by post-transcriptional and post-translational modifications / $c O. Zenata, R. Vrzal,
- 520 9_
- $a Vitamin D receptor (VDR) is a member of the nuclear receptor (NR) superfamily of ligand-activated transcription factors. Activated VDR is responsible for maintaining calcium and phosphate homeostasis, and is required for proper cellular growth, cell differentiation and apoptosis. The expression of both phases I and II drug-metabolizing enzymes is also regulated by VDR, therefore it is clinically important.Post-translational modifications of NRs have been known as an important mechanism modulating the activity of NRs and their ability to drive the expression of target genes. The aim of this mini review is to summarize the current knowledge about post-transcriptional and post-translational modifications of VDR.
- 650 _2
- $a regulace genové exprese $7 D005786
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mikro RNA $x genetika $7 D035683
- 650 _2
- $a fosforylace $7 D010766
- 650 12
- $a posttranslační úpravy proteinů $7 D011499
- 650 _2
- $a receptory kalcitriolu $x genetika $x metabolismus $7 D018167
- 650 _2
- $a sumoylace $7 D058207
- 650 _2
- $a genetická transkripce $7 D014158
- 650 _2
- $a ubikvitinace $7 D054875
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Vrzal, Radim $u Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Olomouc, Czech Republic.
- 773 0_
- $w MED00184852 $t Oncotarget $x 1949-2553 $g Roč. 8, č. 21 (2017), s. 35390-35402
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/28427151 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20180404 $b ABA008
- 991 __
- $a 20180404142238 $b ABA008
- 999 __
- $a ok $b bmc $g 1288147 $s 1007474
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2017 $b 8 $c 21 $d 35390-35402 $i 1949-2553 $m Oncotarget $n Oncotarget $x MED00184852
- LZP __
- $a Pubmed-20180404
