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Fine tuning of vitamin D receptor (VDR) activity by post-transcriptional and post-translational modifications
O. Zenata, R. Vrzal,
Language English Country United States
Document type Journal Article, Review
NLK
Free Medical Journals
from 2010
Freely Accessible Journals
from 2010
PubMed Central
from 2010
Europe PubMed Central
from 2010
Open Access Digital Library
from 2010-01-01
- MeSH
- Phosphorylation MeSH
- Transcription, Genetic MeSH
- Humans MeSH
- MicroRNAs genetics MeSH
- Protein Processing, Post-Translational * MeSH
- Receptors, Calcitriol genetics metabolism MeSH
- Gene Expression Regulation MeSH
- Sumoylation MeSH
- Ubiquitination MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Vitamin D receptor (VDR) is a member of the nuclear receptor (NR) superfamily of ligand-activated transcription factors. Activated VDR is responsible for maintaining calcium and phosphate homeostasis, and is required for proper cellular growth, cell differentiation and apoptosis. The expression of both phases I and II drug-metabolizing enzymes is also regulated by VDR, therefore it is clinically important.Post-translational modifications of NRs have been known as an important mechanism modulating the activity of NRs and their ability to drive the expression of target genes. The aim of this mini review is to summarize the current knowledge about post-transcriptional and post-translational modifications of VDR.
Department of Cell Biology and Genetics Faculty of Science Palacky University Olomouc Czech Republic
References provided by Crossref.org
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