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Cerium dioxide nanoparticles possess anti-inflammatory properties in the conditions of the obesity-associated NAFLD in rats

N. Kobyliak, O. Virchenko, T. Falalyeyeva, M. Kondro, T. Beregova, P. Bodnar, O. Shcherbakov, R. Bubnov, M. Caprnda, D. Delev, J. Sabo, P. Kruzliak, L. Rodrigo, R. Opatrilova, M. Spivak,

. 2017 ; 90 (-) : 608-614. [pub] 20170412

Jazyk angličtina Země Francie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc18010673

BACKGROUND: Obesity is a risk factor for non-alcoholic fatty liver disease (NAFLD). The disease is associated with impairment of pro/antioxidant equilibrium and the inflammation in liver tissue. The aim of the work was to investigate the anti-inflammatory properties of the nanocrystalline cerium dioxide (nCeO2) on the rat model of NAFLD associated with monosodium glutamate (MSG)-induced obesity. METHODS: The study was carried out on three groups of rats: control, MSG- and MSG+nCeO2. They were injected with saline (control) or MSG. A month after born MSG-rats had been treated with water in a volume of 2.9ml/kg, MSG+CeO2groups - with CeO2intragastrically (i.g.). The anthropometric and carbohydrate metabolism parameters, content of proinflammatory cytokines (interleukin (IL)-1β, IL-12Bp40, interferon-γ (INF-γ)) and anti-inflammatory cytokines (IL-4, IL-10, tumor growth factor-β (TGF-β)) were measured by ELISA. RESULTS: We have demonstrated the anti-obesity effect of nanocrystalline cerium dioxide and for the first time its anti-inflammatory properties. Nanoparticles reduced the content of pro-inflammatory cytokines (IL-1β, IL-12Bp40) in rat serum and restored the level of anti-inflammatory cytokines (IL-4, IL-10, TGF-β) to the control values. CONCLUSION: The precise mechanisms of this phenomenon remain to be unclear but we suppose they are at least partially associated with the strong anti-oxidant action of studied substance. Nanocrystalline cerium dioxide attenuates the inflammatory processes in rat blood that can prevent obesity complications and liver injury.

Citace poskytuje Crossref.org

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$a BACKGROUND: Obesity is a risk factor for non-alcoholic fatty liver disease (NAFLD). The disease is associated with impairment of pro/antioxidant equilibrium and the inflammation in liver tissue. The aim of the work was to investigate the anti-inflammatory properties of the nanocrystalline cerium dioxide (nCeO2) on the rat model of NAFLD associated with monosodium glutamate (MSG)-induced obesity. METHODS: The study was carried out on three groups of rats: control, MSG- and MSG+nCeO2. They were injected with saline (control) or MSG. A month after born MSG-rats had been treated with water in a volume of 2.9ml/kg, MSG+CeO2groups - with CeO2intragastrically (i.g.). The anthropometric and carbohydrate metabolism parameters, content of proinflammatory cytokines (interleukin (IL)-1β, IL-12Bp40, interferon-γ (INF-γ)) and anti-inflammatory cytokines (IL-4, IL-10, tumor growth factor-β (TGF-β)) were measured by ELISA. RESULTS: We have demonstrated the anti-obesity effect of nanocrystalline cerium dioxide and for the first time its anti-inflammatory properties. Nanoparticles reduced the content of pro-inflammatory cytokines (IL-1β, IL-12Bp40) in rat serum and restored the level of anti-inflammatory cytokines (IL-4, IL-10, TGF-β) to the control values. CONCLUSION: The precise mechanisms of this phenomenon remain to be unclear but we suppose they are at least partially associated with the strong anti-oxidant action of studied substance. Nanocrystalline cerium dioxide attenuates the inflammatory processes in rat blood that can prevent obesity complications and liver injury.
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$a Virchenko, Oleksandr $u Department of Biology, Bogomolets National Medical University, Kyiv, Ukraine.
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$a Falalyeyeva, Tetyana $u Institute of Biology, Taras Shevchenko National University, Kyiv, Ukraine.
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$a Kondro, Maryana $u Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.
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$a Beregova, Tetyana $u Institute of Biology, Taras Shevchenko National University, Kyiv, Ukraine.
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$a Bodnar, Petro $u Endocrinology Department, Bogomolets National Medical University, Kyiv, Ukraine.
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$a Shcherbakov, Oleksandr $u Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
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$a Bubnov, Rostyslav $u Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
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$a Caprnda, Martin $u 2nd Department of Internal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
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$a Delev, Delian $u Department Pharmacology and Clinical Pharmacology, Medical Faculty, Medical University of Plovdiv, Plovdiv, Bulgaria.
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$a Sabo, Jan $u Department of Medical and Clinical Biophysics, Faculty of Medicine, Pavol Jozef Safarik University, Trieda SNP 1, Kosice, 040 11, Slovakia. Electronic address: jan.sabo@upjs.sk.
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$a Kruzliak, Peter $u Research and Development Services, Brno, Czech Republic; Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho tr. 1/1946, Brno, 612 42, Czech Republic; 2nd Department of Surgery, Faculty of Medicine, Masaryk University a St. Anne's University Hospital, Brno, Czech Republic. Electronic address: kruzliakpeter@gmail.com.
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$a Rodrigo, Luis $u Faculty of Medicine, University of Oviedo, Central University Hospital of Asturias (HUCA), Oviedo, Asturias, Spain.
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