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AllergoOncology - the impact of allergy in oncology: EAACI position paper

E. Jensen-Jarolim, HJ. Bax, R. Bianchini, M. Capron, C. Corrigan, M. Castells, D. Dombrowicz, TR. Daniels-Wells, J. Fazekas, E. Fiebiger, S. Gatault, HJ. Gould, J. Janda, DH. Josephs, P. Karagiannis, F. Levi-Schaffer, A. Meshcheryakova, D....

. 2017 ; 72 (6) : 866-887. [pub] 20170123

Jazyk angličtina Země Dánsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc18010878

Th2 immunity and allergic immune surveillance play critical roles in host responses to pathogens, parasites and allergens. Numerous studies have reported significant links between Th2 responses and cancer, including insights into the functions of IgE antibodies and associated effector cells in both antitumour immune surveillance and therapy. The interdisciplinary field of AllergoOncology was given Task Force status by the European Academy of Allergy and Clinical Immunology in 2014. Affiliated expert groups focus on the interface between allergic responses and cancer, applied to immune surveillance, immunomodulation and the functions of IgE-mediated immune responses against cancer, to derive novel insights into more effective treatments. Coincident with rapid expansion in clinical application of cancer immunotherapies, here we review the current state-of-the-art and future translational opportunities, as well as challenges in this relatively new field. Recent developments include improved understanding of Th2 antibodies, intratumoral innate allergy effector cells and mediators, IgE-mediated tumour antigen cross-presentation by dendritic cells, as well as immunotherapeutic strategies such as vaccines and recombinant antibodies, and finally, the management of allergy in daily clinical oncology. Shedding light on the crosstalk between allergic response and cancer is paving the way for new avenues of treatment.

Center Pigmod Institute of Animal Physiology and Genetics Academy of Sciences of Czech Republic Libechov Czech Republic

Department of Biomedical Sciences Nazarbayev University School of Medicine Astana Kazakhstan

Division of Asthma Allergy and Lung Biology Medical Research Council and Asthma UK Centre in Allergic Mechanisms in Asthma King's College London London UK

Division of Asthma Allergy and Lung Biology Medical Research Council and Asthma UK Centre in Allergic Mechanisms in Asthma King's College London London UK Randall Division of Cell and Molecular Biophysics King's College London London UK NIHR Biomedical Research Centre at Guy's and St Thomas' Hospitals and King's College London King's College London Guy's Hospital London UK

Division of Cancer Studies Faculty of Life Sciences and Medicine King's College London Guy's Hospital London UK NIHR Biomedical Research Centre at Guy's and St Thomas' Hospitals and King's College London King's College London Guy's Hospital London UK

Division of Gastroenterology Hepatology and Nutrition Research Department of Medicine Research Children's University Hospital Boston Boston MA USA

Division of Genetics and Molecular Medicine Faculty of Life Sciences and Medicine St John's Institute of Dermatology King's College London London UK Division of Cancer Studies Faculty of Life Sciences and Medicine King's College London Guy's Hospital London UK

Division of Genetics and Molecular Medicine Faculty of Life Sciences and Medicine St John's Institute of Dermatology King's College London London UK NIHR Biomedical Research Centre at Guy's and St Thomas' Hospitals and King's College London King's College London Guy's Hospital London UK

Division of Pharmacology Faculty of Science Utrecht Institute for Pharmaceutical Sciences Utrecht University Utrecht The Netherlands

Division of Rheumatology Immunology and Allergy Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston MA USA

Division of Surgical Oncology Department of Surgery David Geffen School of Medicine at UCLA Los Angeles CA USA

Division of Surgical Oncology Department of Surgery David Geffen School of Medicine at UCLA Los Angeles CA USA Department of Microbiology Immunology and Molecular Genetics David Geffen School of Medicine at UCLA Los Angeles CA USA Jonsson Comprehensive Cancer Center University of California Los Angeles CA USA

Immunological Engineering Department of Engineering Aarhus University Aarhus Denmark

INSERM CHU Lille European Genomic Institute of Diabetes Institut Pasteur de Lille U1011 récepteurs nucléaires maladies cardiovasculaires et diabète Université de Lille Lille France

Institute of Pathophysiology and Allergy Research Center of Pathophysiology Infectiology and Immunology Medical University Vienna Vienna Austria

IRCCS San Raffaele Scientific Institute Milan Italy

ISGlobal Centre for Research in Environmental Epidemiology Madrid Spain McLaughlin Centre for Population Health Risk Assessment University of Ottawa Ottawa ON Canada

LIRIC Unité Mixte de Recherche 995 INSERM Université de Lille 2 CHRU de Lille Lille France

Pharmacology and Experimental Therapeutics Unit Faculty of Medicine School of Pharmacy The Institute for Drug Research The Hebrew University of Jerusalem Jerusalem Israel

Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel

The Interuniversity Messerli Research Institute University of Veterinary Medicine Vienna Medical University of Vienna Vienna Austria

The Interuniversity Messerli Research Institute University of Veterinary Medicine Vienna Medical University of Vienna Vienna Austria Institute of Pathophysiology and Allergy Research Center of Pathophysiology Infectiology and Immunology Medical University Vienna Vienna Austria

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