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Vitamin D Receptor TaqI Gene Polymorphism and Dental Caries in Czech Children

L. Izakovicova Holla, P. Borilova Linhartova, J. Kastovsky, M. Bartosova, K. Musilova, L. Kukla, M. Kukletova,

. 2017 ; 51 (1) : 7-11. [pub] 20161126

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc18010917

AIM: We analyzed the VDR TaqI (rs731236) gene polymorphism in children with and those without dental caries. METHODS: A total of 388 subjects, 153 caries-free (with decayed/missing/filled teeth [DMFT] = 0) and 235 children with dental caries (DMFT ≥1), were genotyped by the TaqMan method. RESULTS: Although no significant differences in VDR TaqI allele and genotype frequencies between caries-free and caries-affected children were detected, a significant association between this polymorphism and gingivitis was found (p < 0.05). CONCLUSIONS: In contrast to previous studies from China and Turkey, the VDR TaqI gene variant cannot be used as a marker for identification of Czech children with increased dental caries risk.

Citace poskytuje Crossref.org

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