• Something wrong with this record ?

Evidence for widespread infection of African bats with Crimean-Congo hemorrhagic fever-like viruses

MA. Müller, S. Devignot, E. Lattwein, VM. Corman, GD. Maganga, F. Gloza-Rausch, T. Binger, P. Vallo, P. Emmerich, VM. Cottontail, M. Tschapka, S. Oppong, JF. Drexler, F. Weber, EM. Leroy, C. Drosten,

. 2016 ; 6 (-) : 26637. [pub] 20160524

Language English Country Great Britain

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc18011205

Crimean Congo hemorrhagic fever virus (CCHFV) is a highly virulent tick-borne pathogen that causes hemorrhagic fever in humans. The geographic range of human CCHF cases largely reflects the presence of ticks. However, highly similar CCHFV lineages occur in geographically distant regions. Tick-infested migratory birds have been suggested, but not confirmed, to contribute to the dispersal. Bats have recently been shown to carry nairoviruses distinct from CCHFV. In order to assess the presence of CCHFV in a wide range of bat species over a wide geographic range, we analyzed 1,135 sera from 16 different bat species collected in Congo, Gabon, Ghana, Germany, and Panama. Using a CCHFV glycoprotein-based indirect immunofluorescence test (IIFT), we identified reactive antibodies in 10.0% (114/1,135) of tested bats, pertaining to 12/16 tested species. Depending on the species, 3.6%-42.9% of cave-dwelling bats and 0.6%-7.1% of foliage-living bats were seropositive (two-tailed t-test, p = 0.0447 cave versus foliage). 11/30 IIFT-reactive sera from 10 different African bat species had neutralizing activity in a virus-like particle assay. Neutralization of full CCHFV was confirmed in 5 of 7 sera. Widespread infection of cave-dwelling bats may indicate a role for bats in the life cycle and geographic dispersal of CCHFV.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc18011205
003      
CZ-PrNML
005      
20180404142629.0
007      
ta
008      
180404s2016 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1038/srep26637 $2 doi
035    __
$a (PubMed)27217069
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Müller, Marcel A $u University of Bonn Medical Centre, Bonn, Germany.
245    10
$a Evidence for widespread infection of African bats with Crimean-Congo hemorrhagic fever-like viruses / $c MA. Müller, S. Devignot, E. Lattwein, VM. Corman, GD. Maganga, F. Gloza-Rausch, T. Binger, P. Vallo, P. Emmerich, VM. Cottontail, M. Tschapka, S. Oppong, JF. Drexler, F. Weber, EM. Leroy, C. Drosten,
520    9_
$a Crimean Congo hemorrhagic fever virus (CCHFV) is a highly virulent tick-borne pathogen that causes hemorrhagic fever in humans. The geographic range of human CCHF cases largely reflects the presence of ticks. However, highly similar CCHFV lineages occur in geographically distant regions. Tick-infested migratory birds have been suggested, but not confirmed, to contribute to the dispersal. Bats have recently been shown to carry nairoviruses distinct from CCHFV. In order to assess the presence of CCHFV in a wide range of bat species over a wide geographic range, we analyzed 1,135 sera from 16 different bat species collected in Congo, Gabon, Ghana, Germany, and Panama. Using a CCHFV glycoprotein-based indirect immunofluorescence test (IIFT), we identified reactive antibodies in 10.0% (114/1,135) of tested bats, pertaining to 12/16 tested species. Depending on the species, 3.6%-42.9% of cave-dwelling bats and 0.6%-7.1% of foliage-living bats were seropositive (two-tailed t-test, p = 0.0447 cave versus foliage). 11/30 IIFT-reactive sera from 10 different African bat species had neutralizing activity in a virus-like particle assay. Neutralization of full CCHFV was confirmed in 5 of 7 sera. Widespread infection of cave-dwelling bats may indicate a role for bats in the life cycle and geographic dispersal of CCHFV.
650    _2
$a střední Afrika $x epidemiologie $7 D000350
650    _2
$a zvířata $7 D000818
650    12
$a Chiroptera $x krev $x virologie $7 D002685
650    _2
$a Německo $x epidemiologie $7 D005858
650    12
$a virus krymsko-konžské hemoragické horečky $7 D003225
650    12
$a hemoragická horečka krymská $x krev $x epidemiologie $7 D006479
650    _2
$a lidé $7 D006801
650    _2
$a Panama $x epidemiologie $7 D010176
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Devignot, Stéphanie $u University of Marburg, Institute for Virology, Marburg, Germany. Institute for Virology, FB10-Veterinary Medicine, Justus-Liebig University, Giessen, Germany.
700    1_
$a Lattwein, Erik $u EUROIMMUN AG, Lübeck, Germany.
700    1_
$a Corman, Victor Max $u University of Bonn Medical Centre, Bonn, Germany. German Centre for Infection Research (DZIF)-Partner Site Bonn-Cologne, Bonn, Germany.
700    1_
$a Maganga, Gaël D $u Centre International de Recherches Médicales de Franceville, Franceville, Gabon.
700    1_
$a Gloza-Rausch, Florian $u Noctalis, Bad Segeberg, Germany.
700    1_
$a Binger, Tabea $u University of Bonn Medical Centre, Bonn, Germany.
700    1_
$a Vallo, Peter $u Institute of Vertebrate Biology, Academy of Sciences of the Czech Republic, Brno, Czech Republic. University of Ulm, Ulm, Germany.
700    1_
$a Emmerich, Petra $u Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
700    1_
$a Cottontail, Veronika M $u University of Ulm, Ulm, Germany. Smithsonian Tropical Research Institute, Balboa, Panama.
700    1_
$a Tschapka, Marco $u University of Ulm, Ulm, Germany. Smithsonian Tropical Research Institute, Balboa, Panama.
700    1_
$a Oppong, Samuel $u Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
700    1_
$a Drexler, Jan Felix $u University of Bonn Medical Centre, Bonn, Germany. German Centre for Infection Research (DZIF)-Partner Site Bonn-Cologne, Bonn, Germany.
700    1_
$a Weber, Friedemann $u University of Marburg, Institute for Virology, Marburg, Germany. Institute for Virology, FB10-Veterinary Medicine, Justus-Liebig University, Giessen, Germany.
700    1_
$a Leroy, Eric M $u Centre International de Recherches Médicales de Franceville, Franceville, Gabon. Institut de Recherche pour le Développement, Montpellier, France.
700    1_
$a Drosten, Christian $u University of Bonn Medical Centre, Bonn, Germany. German Centre for Infection Research (DZIF)-Partner Site Bonn-Cologne, Bonn, Germany.
773    0_
$w MED00182195 $t Scientific reports $x 2045-2322 $g Roč. 6, č. - (2016), s. 26637
856    41
$u https://pubmed.ncbi.nlm.nih.gov/27217069 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20180404 $b ABA008
991    __
$a 20180404142709 $b ABA008
999    __
$a ok $b bmc $g 1288690 $s 1008017
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2016 $b 6 $c - $d 26637 $e 20160524 $i 2045-2322 $m Scientific reports $n Sci Rep $x MED00182195
LZP    __
$a Pubmed-20180404

Find record

Citation metrics

Archiving options