-
Something wrong with this record ?
TRPV1 receptors contribute to paclitaxel-induced c-Fos expression in spinal cord dorsal horn neurons
N. Kalynovska, P. Adamek, J. Palecek
Language English Country Czech Republic
Document type Journal Article
NLK
Directory of Open Access Journals
from 1991
Free Medical Journals
from 1998
ProQuest Central
from 2005-01-01
Medline Complete (EBSCOhost)
from 2006-01-01
Nursing & Allied Health Database (ProQuest)
from 2005-01-01
Health & Medicine (ProQuest)
from 2005-01-01
ROAD: Directory of Open Access Scholarly Resources
from 1998
- MeSH
- Posterior Horn Cells drug effects metabolism MeSH
- Gene Expression MeSH
- Antineoplastic Agents, Phytogenic pharmacology MeSH
- TRPV Cation Channels antagonists & inhibitors physiology MeSH
- Rats MeSH
- Paclitaxel pharmacology MeSH
- Rats, Wistar MeSH
- Proto-Oncogene Proteins c-fos agonists biosynthesis genetics MeSH
- Spinal Cord Dorsal Horn drug effects metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
Transient receptor potential vanilloid type 1 (TRPV1) receptors are important in the development of different pathological chronic pain states. Here we examined the role of spinal cord TRPV1 receptors in the mechanisms leading to activation of dorsal horn neurons after paclitaxel (PAC) treatment. PAC is a widely used chemotherapeutic drug that often leads to development of painful neuropathy. Immunohistochemical analysis of c-Fos protein expression in dorsal horn neurons was used as a marker of neuronal activation. Rat spinal cord slices were processed for in vitro incubation with PAC (100 nM) and TRPV1 receptor antagonists (SB366791 and AMG9810; 10 microM). PAC treatment induced significant upregulation of c-Fos nuclear expression in superficial dorsal horn neurons that was diminished by TRPV1 receptor antagonists pre-incubation. These results further substantiated the role of spinal TRPV1 receptors in the development of paclitaxel-induced neuropathic pain and contribute to better understanding of the pathological mechanisms involved.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc18016047
- 003
- CZ-PrNML
- 005
- 20190517154039.0
- 007
- ta
- 008
- 180514s2017 xr ad f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.33549/physiolres.933613 $2 doi
- 035 __
- $a (PubMed)28730839
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Kalynovska, Nataliia. $u Department of Functional Morphology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic; Faculty of Sciences, Charles University, Prague, Czech Republic $7 xx0225014
- 245 10
- $a TRPV1 receptors contribute to paclitaxel-induced c-Fos expression in spinal cord dorsal horn neurons / $c N. Kalynovska, P. Adamek, J. Palecek
- 520 9_
- $a Transient receptor potential vanilloid type 1 (TRPV1) receptors are important in the development of different pathological chronic pain states. Here we examined the role of spinal cord TRPV1 receptors in the mechanisms leading to activation of dorsal horn neurons after paclitaxel (PAC) treatment. PAC is a widely used chemotherapeutic drug that often leads to development of painful neuropathy. Immunohistochemical analysis of c-Fos protein expression in dorsal horn neurons was used as a marker of neuronal activation. Rat spinal cord slices were processed for in vitro incubation with PAC (100 nM) and TRPV1 receptor antagonists (SB366791 and AMG9810; 10 microM). PAC treatment induced significant upregulation of c-Fos nuclear expression in superficial dorsal horn neurons that was diminished by TRPV1 receptor antagonists pre-incubation. These results further substantiated the role of spinal TRPV1 receptors in the development of paclitaxel-induced neuropathic pain and contribute to better understanding of the pathological mechanisms involved.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a fytogenní protinádorové látky $x farmakologie $7 D000972
- 650 _2
- $a exprese genu $7 D015870
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a paclitaxel $x farmakologie $7 D017239
- 650 _2
- $a buňky zadních rohů míšních $x účinky léků $x metabolismus $7 D020671
- 650 _2
- $a protoonkogenní proteiny c-fos $x agonisté $x biosyntéza $x genetika $7 D016760
- 650 _2
- $a krysa rodu Rattus $7 D051381
- 650 _2
- $a potkani Wistar $7 D017208
- 650 _2
- $a zadní rohy míšní $x účinky léků $x metabolismus $7 D066148
- 650 _2
- $a kationtové kanály TRPV $x antagonisté a inhibitory $x fyziologie $7 D050916
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Adámek, Petr $7 xx0072983 $u Department of Functional Morphology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic
- 700 1_
- $a Paleček, Jiří $7 xx0089067 $u Department of Functional Morphology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic
- 773 0_
- $w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 66, č. 3 (2017), s. 549-552
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/28730839 $y Pubmed
- 910 __
- $a ABA008 $b A 4120 $c 266 $y 4 $z 0
- 990 __
- $a 20180514 $b ABA008
- 991 __
- $a 20190517154148 $b ABA008
- 999 __
- $a ok $b bmc $g 1303670 $s 1012887
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2017 $b 66 $c 3 $d 549-552 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
- LZP __
- $b NLK118 $a Pubmed-20180514
