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Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
JD. McKay, RJ. Hung, Y. Han, X. Zong, R. Carreras-Torres, DC. Christiani, NE. Caporaso, M. Johansson, X. Xiao, Y. Li, J. Byun, A. Dunning, KA. Pooley, DC. Qian, X. Ji, G. Liu, MN. Timofeeva, SE. Bojesen, X. Wu, L. Le Marchand, D. Albanes, H....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, metaanalýza
NLK
ProQuest Central
od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
PubMed
28604730
DOI
10.1038/ng.3892
Knihovny.cz E-zdroje
- MeSH
- adenokarcinom genetika MeSH
- běloši genetika MeSH
- celogenomová asociační studie * MeSH
- dospělí MeSH
- genetická predispozice k nemoci MeSH
- genotyp MeSH
- homeostáza telomer genetika MeSH
- jednonukleotidový polymorfismus MeSH
- kouření epidemiologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- lokus kvantitativního znaku MeSH
- mapování chromozomů MeSH
- nádory plic epidemiologie etnologie genetika MeSH
- senioři MeSH
- zdraví rodiny MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genome-wide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer.
2nd Faculty of Medicine Charles University Prague Czech Republic
American Cancer Society Atlanta Georgia USA
Biomedical Data Science Geisel School of Medicine at Dartmouth Hanover New Hampshire USA
British Columbia Cancer Agency Vancouver British Columbia Canada
Cancer Division QIMR Berghofer Medical Research Institute Brisbane Queensland Australia
Centre for Cancer Genetic Epidemiology University of Cambridge Cambridge UK
Clinical Center of Serbia Belgrade Serbia School of Medicine University of Belgrade Belgrade Serbia
Department of Clinical Science University of Bergen Bergen Norway
Department of Clinical Sciences and Community Health DISCCO University of Milan Milan Italy
Department of Epidemiology Geisel School of Medicine Hanover New Hampshire USA
Department of Epidemiology Harvard T H Chan School of Public Health Boston Massachusetts USA
Department of Epidemiology Shanghai Cancer Institute Shanghai China
Department of Epidemiology University of Texas MD Anderson Cancer Center Houston Texas USA
Department of Epidemiology University of Washington Seattle Washington USA
Department of Integrative Bioscience and Biotechnology Sejong University Seoul Republic of Korea
Department of Medical Biosciences Umeå University Umeå Sweden
Department of Oncology University of Sheffield Sheffield UK
Department of Pathology Lund University Lund Sweden
Department of Psychiatry Washington University School of Medicine St Louis Missouri USA
Department of Radiation Sciences Umeå University Umeå Sweden
Department of Surgery National Tuberculosis and Lung Diseases Research Institute Warsaw Poland
Department of Thoracic Oncology H Lee Moffitt Cancer Center and Research Institute Tampa Florida USA
Duke National University of Singapore Medical School Singapore
Duncan Cancer Center Baylor College of Medicine Houston Texas USA
eCODE Genetics Amgen Inc Reykjavik Iceland
Epidemiology Program University of Hawaii Cancer Center Honolulu Hawaii USA
Faculty of Medicine Lund University Lund Sweden
Faculty of Medicine University of Ostrava Ostrava Czech Republic
Hellenic Health Foundation Athens Greece
Institut Universitaire de Cardiologie et de Pneumologie de Québec Québec Québec Canada
Institute of Pneumology 'Marius Nasta' Bucharest Romania
Institute of Translational Medicine University of Liverpool Liverpool UK
International Agency for Research on Cancer World Health Organization Lyon France
International Organization for Cancer Prevention and Research Belgrade Serbia
M Sklodowska Curie Cancer Center Institute of Oncology Warsaw Poland
Markey Cancer Center University of Kentucky Lexington Kentucky USA
Merck Research Laboratories Genetics and Pharmacogenomics Boston Massachusetts USA
Molecular and Nutritional Epidemiology Unit CSPO Scientific Institute of Tuscany Florence Italy
National Institute of Occupational Health Oslo Norway
Nofer Institute of Occupational Medicine Department of Environmental Epidemiology Lodz Poland
Program in Epidemiology Fred Hutchinson Cancer Research Center Seattle Washington USA
Public Health Ontario Toronto Ontario Canada
Research Computing Division RTI International Research Triangle Park North Carolina USA
School of Health and Related Research University of Sheffield Sheffield UK
School of Public Health St Mary's Campus Imperial College London London UK
Section for Epidemiology Department of Public Health Aarhus University Aarhus Denmark
Swedish Medical Group Seattle Washington USA
The Institute of Cancer Research London UK
Unit of Nutrition and Cancer Catalan Institute of Oncology Barcelona Spain
University Health Network Princess Margaret Cancer Centre Toronto Ontario Canada
University of Oviedo and CIBERESP Faculty of Medicine Oviedo Spain
University of Pittsburgh Cancer Institute Pittsburgh Pennsylvania USA
Citace poskytuje Crossref.org
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