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A matter of maturity: The impact of pre-mRNA processing in gene expression and antigen presentation
RP. Martins, R. Fåhraeus,
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články, přehledy, práce podpořená grantem
- MeSH
- buněčné jádro metabolismus MeSH
- lidé MeSH
- posttranskripční úpravy RNA * MeSH
- prekurzory RNA biosyntéza genetika metabolismus MeSH
- prezentace antigenu genetika MeSH
- regulace genové exprese MeSH
- virové nemoci genetika imunologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
RNA processing plays a pivotal role in the diversification of high eukaryotes transcriptome and proteome. The expression of gene products controlling a variety of cellular and physiological processes depends largely on a complex maturation process undergone by pre-mRNAs to become translation-competent mRNAs. Here we review the different mechanisms involved in the pre-mRNA processing and disclose their impact in the gene regulation process in eukaryotic cells. We describe some viral strategies targeting pre-mRNA processing to control gene expression and host immune response and discuss their relevance as tools for a better understanding of cell biology. Finally, we highlight accumulating evidences toward the occurrence of a translation event coupled to mRNA biogenesis in the nuclear compartment and argue how this is relevant for the production of antigenic peptide substrates for the major histocompatibility complex class I pathway.
Department of Medical Biosciences Umeå University Umeå Sweden
RECAMO Masaryk Memorial Cancer Institute Brno Czech Republic
Citace poskytuje Crossref.org
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- $a Martins, Rodrigo Prado $u Équipe Labellisée Ligue Contre le Cancer, Université Paris 7, INSERM UMR 1162, 27 rue Juliette Dodu, 75010 Paris, France. Electronic address: rodrigo.prado-martins@inserm.fr.
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