Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Common Chemical Inductors of Replication Stress: Focus on Cell-Based Studies

E. Vesela, K. Chroma, Z. Turi, M. Mistrik,

. 2017 ; 7 (1) : . [pub] 20170221

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc18016755

DNA replication is a highly demanding process regarding the energy and material supply and must be precisely regulated, involving multiple cellular feedbacks. The slowing down or stalling of DNA synthesis and/or replication forks is referred to as replication stress (RS). Owing to the complexity and requirements of replication, a plethora of factors may interfere and challenge the genome stability, cell survival or affect the whole organism. This review outlines chemical compounds that are known inducers of RS and commonly used in laboratory research. These compounds act on replication by direct interaction with DNA causing DNA crosslinks and bulky lesions (cisplatin), chemical interference with the metabolism of deoxyribonucleotide triphosphates (hydroxyurea), direct inhibition of the activity of replicative DNA polymerases (aphidicolin) and interference with enzymes dealing with topological DNA stress (camptothecin, etoposide). As a variety of mechanisms can induce RS, the responses of mammalian cells also vary. Here, we review the activity and mechanism of action of these compounds based on recent knowledge, accompanied by examples of induced phenotypes, cellular readouts and commonly used doses.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc18016755
003      
CZ-PrNML
005      
20180523132211.0
007      
ta
008      
180515s2017 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/biom7010019 $2 doi
035    __
$a (PubMed)28230817
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Vesela, Eva $u Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 5, Olomouc 779 00, Czech Republic. eva.vesela@upol.cz. MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK. eva.vesela@upol.cz.
245    10
$a Common Chemical Inductors of Replication Stress: Focus on Cell-Based Studies / $c E. Vesela, K. Chroma, Z. Turi, M. Mistrik,
520    9_
$a DNA replication is a highly demanding process regarding the energy and material supply and must be precisely regulated, involving multiple cellular feedbacks. The slowing down or stalling of DNA synthesis and/or replication forks is referred to as replication stress (RS). Owing to the complexity and requirements of replication, a plethora of factors may interfere and challenge the genome stability, cell survival or affect the whole organism. This review outlines chemical compounds that are known inducers of RS and commonly used in laboratory research. These compounds act on replication by direct interaction with DNA causing DNA crosslinks and bulky lesions (cisplatin), chemical interference with the metabolism of deoxyribonucleotide triphosphates (hydroxyurea), direct inhibition of the activity of replicative DNA polymerases (aphidicolin) and interference with enzymes dealing with topological DNA stress (camptothecin, etoposide). As a variety of mechanisms can induce RS, the responses of mammalian cells also vary. Here, we review the activity and mechanism of action of these compounds based on recent knowledge, accompanied by examples of induced phenotypes, cellular readouts and commonly used doses.
650    _2
$a zvířata $7 D000818
650    _2
$a protinádorové látky $x chemie $x farmakologie $7 D000970
650    _2
$a buňky $x účinky léků $x metabolismus $7 D002477
650    12
$a replikace DNA $x účinky léků $7 D004261
650    _2
$a lidé $7 D006801
650    12
$a fyziologický stres $x účinky léků $7 D013312
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Chroma, Katarina $u Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 5, Olomouc 779 00, Czech Republic. katarina.chroma@upol.cz.
700    1_
$a Turi, Zsofia $u Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 5, Olomouc 779 00, Czech Republic. zsofia.turi01@upol.cz.
700    1_
$a Mistrik, Martin $u Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 5, Olomouc 779 00, Czech Republic. martin.mistrik@upol.cz.
773    0_
$w MED00188737 $t Biomolecules $x 2218-273X $g Roč. 7, č. 1 (2017)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28230817 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20180515 $b ABA008
991    __
$a 20180523132355 $b ABA008
999    __
$a ok $b bmc $g 1300379 $s 1013595
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 7 $c 1 $e 20170221 $i 2218-273X $m Biomolecules $n Biomolecules $x MED00188737
LZP    __
$a Pubmed-20180515

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace