-
Je něco špatně v tomto záznamu ?
Characteristics and risk profile of psoriasis patients included in the Czech national registry BIOREP and a comparison with other registries
M. Kojanova, J. Fialova, P. Cetkovska, S. Gkalpakiotis, J. Jircikova, T. Dolezal, P. Arenberger, . ,
Jazyk angličtina Země Velká Británie
Typ dokumentu srovnávací studie, časopisecké články
PubMed
28181669
DOI
10.1111/ijd.13543
Knihovny.cz E-zdroje
- MeSH
- acitretin terapeutické užití MeSH
- biologické přípravky terapeutické užití MeSH
- cyklosporin terapeutické užití MeSH
- dermatologické látky terapeutické užití MeSH
- diabetes mellitus epidemiologie MeSH
- dospělí MeSH
- fototerapie MeSH
- hyperlipidemie epidemiologie MeSH
- hypertenze epidemiologie MeSH
- index tělesné hmotnosti MeSH
- keratolytika terapeutické užití MeSH
- komorbidita MeSH
- koronární nemoc epidemiologie MeSH
- kvalita života MeSH
- lidé středního věku MeSH
- lidé MeSH
- methotrexát terapeutické užití MeSH
- obezita epidemiologie MeSH
- opakovaná terapie MeSH
- prevalence MeSH
- psoriáza farmakoterapie epidemiologie terapie MeSH
- registrace MeSH
- retrospektivní studie MeSH
- rizikové faktory MeSH
- stupeň závažnosti nemoci MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
BACKGROUND: BIOREP is a Czech registry of psoriatic patients on biological treatment in a clinical setting. We describe the characteristics of patients with psoriasis at the time of enrollment and present comparisons with published data from other national registries. METHODS: We analyzed the cohort of patients treated with biologics between May 2005 and May 2015. Demographic data, previous therapies, comorbidities, and severity of psoriasis were compared with data from other registries - DERMBIO, BIOBADADERM, BADBIR, and PSOBEST. RESULTS: A total of 1412 psoriatic patients initiating biological treatment were included with a predominance of males (63.4%). The mean patient age was 50.2 years, and approximately 70.5% of patients were either overweight or obese. The mean baseline Psoriasis Area and Severity Index was 19.8, and the Dermatology Life Quality Index was 16.6. More than one-third of patients (41.0%) reported a history of psoriatic arthritis, and a high proportion of patients (49.5%) with cardiovascular risk factors (hypertension [35.2%], hyperlipidemia [27.7%], diabetes mellitus [11.4%], coronary heart disease [4.9%], and obesity [15.2%]) were observed. Most of the patients had been previously treated with phototherapy (85.4%), acitretin (74.0%), methotrexate (65.7%), or cyclosporine (53.1%). CONCLUSION: BIOREP is one of the first registries of patients with psoriasis treated with biologics in Central and Eastern Europe. Our results found a similar or higher prevalence of comorbidities, long disease duration, and high impact on the quality of life among patients included in Western European registries.
- 000
- 00000naa a2200000 a 4500
- 001
- bmc18016775
- 003
- CZ-PrNML
- 005
- 20180516140638.0
- 007
- ta
- 008
- 180515s2017 xxk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1111/ijd.13543 $2 doi
- 035 __
- $a (PubMed)28181669
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Kojanova, Martina $u Department of Dermatovenereology, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic.
- 245 10
- $a Characteristics and risk profile of psoriasis patients included in the Czech national registry BIOREP and a comparison with other registries / $c M. Kojanova, J. Fialova, P. Cetkovska, S. Gkalpakiotis, J. Jircikova, T. Dolezal, P. Arenberger, . ,
- 520 9_
- $a BACKGROUND: BIOREP is a Czech registry of psoriatic patients on biological treatment in a clinical setting. We describe the characteristics of patients with psoriasis at the time of enrollment and present comparisons with published data from other national registries. METHODS: We analyzed the cohort of patients treated with biologics between May 2005 and May 2015. Demographic data, previous therapies, comorbidities, and severity of psoriasis were compared with data from other registries - DERMBIO, BIOBADADERM, BADBIR, and PSOBEST. RESULTS: A total of 1412 psoriatic patients initiating biological treatment were included with a predominance of males (63.4%). The mean patient age was 50.2 years, and approximately 70.5% of patients were either overweight or obese. The mean baseline Psoriasis Area and Severity Index was 19.8, and the Dermatology Life Quality Index was 16.6. More than one-third of patients (41.0%) reported a history of psoriatic arthritis, and a high proportion of patients (49.5%) with cardiovascular risk factors (hypertension [35.2%], hyperlipidemia [27.7%], diabetes mellitus [11.4%], coronary heart disease [4.9%], and obesity [15.2%]) were observed. Most of the patients had been previously treated with phototherapy (85.4%), acitretin (74.0%), methotrexate (65.7%), or cyclosporine (53.1%). CONCLUSION: BIOREP is one of the first registries of patients with psoriasis treated with biologics in Central and Eastern Europe. Our results found a similar or higher prevalence of comorbidities, long disease duration, and high impact on the quality of life among patients included in Western European registries.
- 650 _2
- $a acitretin $x terapeutické užití $7 D017255
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a biologické přípravky $x terapeutické užití $7 D001688
- 650 _2
- $a index tělesné hmotnosti $7 D015992
- 650 _2
- $a komorbidita $7 D015897
- 650 _2
- $a koronární nemoc $x epidemiologie $7 D003327
- 650 _2
- $a cyklosporin $x terapeutické užití $7 D016572
- 650 _2
- $a Česká republika $x epidemiologie $7 D018153
- 650 _2
- $a dermatologické látky $x terapeutické užití $7 D003879
- 650 _2
- $a diabetes mellitus $x epidemiologie $7 D003920
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a hyperlipidemie $x epidemiologie $7 D006949
- 650 _2
- $a hypertenze $x epidemiologie $7 D006973
- 650 _2
- $a keratolytika $x terapeutické užití $7 D007641
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a methotrexát $x terapeutické užití $7 D008727
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a obezita $x epidemiologie $7 D009765
- 650 _2
- $a fototerapie $7 D010789
- 650 _2
- $a prevalence $7 D015995
- 650 _2
- $a psoriáza $x farmakoterapie $x epidemiologie $x terapie $7 D011565
- 650 _2
- $a kvalita života $7 D011788
- 650 _2
- $a registrace $7 D012042
- 650 _2
- $a opakovaná terapie $7 D019233
- 650 _2
- $a retrospektivní studie $7 D012189
- 650 _2
- $a rizikové faktory $7 D012307
- 650 _2
- $a stupeň závažnosti nemoci $7 D012720
- 655 _2
- $a srovnávací studie $7 D003160
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Fialova, Jorga $u Department of Dermatovenereology, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic.
- 700 1_
- $a Cetkovska, Petra $u Department of Dermatovenereology, Charles University, Faculty of Medicine and University Hospital, Pilsen, Czech Republic.
- 700 1_
- $a Gkalpakiotis, Spyridon $u Department of Dermatovenereology, Charles University, Third Faculty of Medicine and Faculty Hospital of Kralovske Vinohrady, Prague, Czech Republic.
- 700 1_
- $a Jircikova, Jitka $u VALUE OUTCOMES, Prague, Czech Republic.
- 700 1_
- $a Dolezal, Tomas $u VALUE OUTCOMES, Prague, Czech Republic.
- 700 1_
- $a Arenberger, Petr $u Department of Dermatovenereology, Charles University, Third Faculty of Medicine and Faculty Hospital of Kralovske Vinohrady, Prague, Czech Republic.
- 700 1_
- $a ,
- 773 0_
- $w MED00009891 $t International journal of dermatology $x 1365-4632 $g Roč. 56, č. 4 (2017), s. 428-434
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/28181669 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20180515 $b ABA008
- 991 __
- $a 20180516140813 $b ABA008
- 999 __
- $a ok $b bmc $g 1300399 $s 1013615
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2017 $b 56 $c 4 $d 428-434 $e 20170209 $i 1365-4632 $m International journal of dermatology $n Int J Dermatol $x MED00009891
- LZP __
- $a Pubmed-20180515