• Je něco špatně v tomto záznamu ?

KCNJ11 and KCNQ1 gene polymorphisms are not associated with post-transplant diabetes mellitus in kidney allograft recipients treated with tacrolimus

E. Dabrowska-Zamojcin, M. Tarnowski, M. Szydlowski, M. Romanowski, V. Dziedziejko, K. Safranow, L. Domanski, A. Pawlik

. 2017 ; 63 (3) : 115-119.

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc18020895

Post-transplant diabetes mellitus (PTDM) is a metabolic disorder occurring after solid organ transplantation during the therapy with calcineurin inhibitors. ATP-sensitive potassium channels KCNJ11 and KCNQ1 play an important role in the regulation of insulin secretion by β cells and development of diabetes mellitus. Numerous studies have confirmed the association between KCNJ11 and KCNQ1 gene polymorphisms and type 2 diabetes. The aim of this study was to examine the association between KCNJ11 and KCNQ1 gene polymorphisms and posttransplant diabetes mellitus in kidney allograft recipients treated with tacrolimus. The study included 201 patients who received kidney transplants. The patients were subdivided into two subgroups: patients with PTDM (N = 35) and patients without PTDM (N = 166). The association between KCNJ11 and KCNQ1 gene polymorphisms and post-transplant diabetes was studied in three models of univariate Cox regression analysis, i.e., additive, dominant and recessive. In these three models there were no statistically significant associations between KCNJ11 and KCNQ1 gene polymorphisms and PTDM. The results of this study suggest lack of association between KCNJ11 and KCNQ1 gene polymorphisms and post-transplant diabetes mellitus in kidney allograft recipients treated with tacrolimus in the Polish population.

000      
00000naa a2200000 a 4500
001      
bmc18020895
003      
CZ-PrNML
005      
20180723083946.0
007      
ta
008      
180608s2017 xr f 000 0|eng||
009      
AR
035    __
$a (PubMed)28805561
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Dabrowska-Zamojcin, E. $u Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland
245    10
$a KCNJ11 and KCNQ1 gene polymorphisms are not associated with post-transplant diabetes mellitus in kidney allograft recipients treated with tacrolimus / $c E. Dabrowska-Zamojcin, M. Tarnowski, M. Szydlowski, M. Romanowski, V. Dziedziejko, K. Safranow, L. Domanski, A. Pawlik
520    9_
$a Post-transplant diabetes mellitus (PTDM) is a metabolic disorder occurring after solid organ transplantation during the therapy with calcineurin inhibitors. ATP-sensitive potassium channels KCNJ11 and KCNQ1 play an important role in the regulation of insulin secretion by β cells and development of diabetes mellitus. Numerous studies have confirmed the association between KCNJ11 and KCNQ1 gene polymorphisms and type 2 diabetes. The aim of this study was to examine the association between KCNJ11 and KCNQ1 gene polymorphisms and posttransplant diabetes mellitus in kidney allograft recipients treated with tacrolimus. The study included 201 patients who received kidney transplants. The patients were subdivided into two subgroups: patients with PTDM (N = 35) and patients without PTDM (N = 166). The association between KCNJ11 and KCNQ1 gene polymorphisms and post-transplant diabetes was studied in three models of univariate Cox regression analysis, i.e., additive, dominant and recessive. In these three models there were no statistically significant associations between KCNJ11 and KCNQ1 gene polymorphisms and PTDM. The results of this study suggest lack of association between KCNJ11 and KCNQ1 gene polymorphisms and post-transplant diabetes mellitus in kidney allograft recipients treated with tacrolimus in the Polish population.
650    _2
$a dospělí $7 D000328
650    _2
$a diabetes mellitus 2. typu $x genetika $x chirurgie $7 D003924
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a draslíkový kanál KCNQ1 $x genetika $7 D051657
650    _2
$a transplantace ledvin $x metody $7 D016030
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a polymorfismus genetický $x genetika $7 D011110
650    _2
$a draslíkové kanály dovnitř usměrňující $x genetika $7 D024661
650    _2
$a takrolimus $x terapeutické užití $7 D016559
655    _2
$a časopisecké články $7 D016428
700    1_
$a Tarnowski, M. $u Department of Physiology, Pomeranian Medical University, Szczecin, Poland
700    1_
$a Szydlowski, M. $u Department of Physiology, Pomeranian Medical University, Szczecin, Poland
700    1_
$a Romanowski, M. $u Department of General and Transplantation, Pomeranian Medical University, Szczecin, Poland
700    1_
$a Dziedziejko, V. $u Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
700    1_
$a Safranow, K. $u Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
700    1_
$a Domanski, L. $u Department of Nephrology and Transplantology, Pomeranian Medical University, Szczecin, Poland
700    1_
$a Pawlik, A. $u Department of Physiology, Pomeranian Medical University, Szczecin, Poland
773    0_
$w MED00011004 $t Folia biologica $x 0015-5500 $g Roč. 63, č. 3 (2017), s. 115-119
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28805561 $y Pubmed
856    41
$u https://fb.cuni.cz/file/5846/fb2017a0017.pdf $y plný text volně přístupný
910    __
$a ABA008 $b A 970 $c 89 $y 4 $z 0
990    __
$a 20180608 $b ABA008
991    __
$a 20180723084250 $b ABA008
999    __
$a ok $b bmc $g 1320409 $s 1017757
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 63 $c 3 $d 115-119 $i 0015-5500 $m Folia biologica (Praha) $n Folia biol. (Praha) $x MED00011004
LZP    __
$b NLK118 $a Pubmed-20180608

Najít záznam

Citační ukazatele

Možnosti archivace