-
Je něco špatně v tomto záznamu ?
A 6-Year Follow-Up of Fracture Incidence and Volumetric Bone Mineral Density Development in Girls With Turner Syndrome
O. Soucek, E. Schönau, J. Lebl, J. Willnecker, Z. Hlavka, Z. Sumnik,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
Odkazy
PubMed
29300907
DOI
10.1210/jc.2017-02381
Knihovny.cz E-zdroje
- MeSH
- časové faktory MeSH
- dítě MeSH
- estrogeny terapeutické užití MeSH
- incidence MeSH
- kostní denzita účinky léků MeSH
- lidé MeSH
- mladiství MeSH
- následné studie MeSH
- osteoporotické fraktury epidemiologie etiologie MeSH
- počítačová rentgenová tomografie metody MeSH
- radius diagnostické zobrazování MeSH
- rizikové faktory MeSH
- růstový hormon terapeutické užití MeSH
- Turnerův syndrom komplikace farmakoterapie patofyziologie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Context: Patients with Turner syndrome (TS) are at risk for osteoporotic fractures. Objective: The aims of this study were to assess the incidence of clinically important fractures in girls with TS and prospectively describe the development of volumetric bone mineral density (BMD). Design: Peripheral quantitative computerized tomography (pQCT) of the radius every other year over the 6 years of observation. Setting: Government-funded university referral center. Participants: Thirty-two girls with TS, aged 6 to 16 years, were included in the analyses. Fracture incidence was compared with the data in the general population. Bone density and strength were compared with data from 185 healthy girls. Outcomes: The main clinical outcome was the fracture occurrence. The secondary outcomes were the changes in Z-scores of the bone parameters. Results: Three girls with TS sustained four fractures during 6 years of observation. The fracture rate in TS was not substantially higher than the downward-biased fracture-rate estimate from age-matched, healthy controls (P = 0.48). Whereas the trabecular BMD Z-score decreased with age (β estimate -0.21 ± 0.04, P < 0.001), total bone cross-sectional area correspondingly increased (+0.16 ± 0.04, P < 0.001), which led to normal bone strength. A positive history of incident fractures was not significantly associated with any of the pQCT-derived bone parameters. Conclusions: Current pediatric TS patients that are treated with growth hormone and estrogens are not at risk for osteoporotic fractures. Low BMD in TS may be counterweighted by enlarged bone radius, which leads to normal bone strength at the appendicular skeleton.
- 000
- 00000naa a2200000 a 4500
- 001
- bmc18024401
- 003
- CZ-PrNML
- 005
- 20180718112432.0
- 007
- ta
- 008
- 180709s2018 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1210/jc.2017-02381 $2 doi
- 035 __
- $a (PubMed)29300907
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Soucek, Ondrej $u Department of Pediatrics, Second Medical Faculty, Charles University in Prague and Motol University Hospital, Prague, Czech Republic.
- 245 12
- $a A 6-Year Follow-Up of Fracture Incidence and Volumetric Bone Mineral Density Development in Girls With Turner Syndrome / $c O. Soucek, E. Schönau, J. Lebl, J. Willnecker, Z. Hlavka, Z. Sumnik,
- 520 9_
- $a Context: Patients with Turner syndrome (TS) are at risk for osteoporotic fractures. Objective: The aims of this study were to assess the incidence of clinically important fractures in girls with TS and prospectively describe the development of volumetric bone mineral density (BMD). Design: Peripheral quantitative computerized tomography (pQCT) of the radius every other year over the 6 years of observation. Setting: Government-funded university referral center. Participants: Thirty-two girls with TS, aged 6 to 16 years, were included in the analyses. Fracture incidence was compared with the data in the general population. Bone density and strength were compared with data from 185 healthy girls. Outcomes: The main clinical outcome was the fracture occurrence. The secondary outcomes were the changes in Z-scores of the bone parameters. Results: Three girls with TS sustained four fractures during 6 years of observation. The fracture rate in TS was not substantially higher than the downward-biased fracture-rate estimate from age-matched, healthy controls (P = 0.48). Whereas the trabecular BMD Z-score decreased with age (β estimate -0.21 ± 0.04, P < 0.001), total bone cross-sectional area correspondingly increased (+0.16 ± 0.04, P < 0.001), which led to normal bone strength. A positive history of incident fractures was not significantly associated with any of the pQCT-derived bone parameters. Conclusions: Current pediatric TS patients that are treated with growth hormone and estrogens are not at risk for osteoporotic fractures. Low BMD in TS may be counterweighted by enlarged bone radius, which leads to normal bone strength at the appendicular skeleton.
- 650 _2
- $a mladiství $7 D000293
- 650 _2
- $a kostní denzita $x účinky léků $7 D015519
- 650 _2
- $a dítě $7 D002648
- 650 _2
- $a estrogeny $x terapeutické užití $7 D004967
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a následné studie $7 D005500
- 650 _2
- $a růstový hormon $x terapeutické užití $7 D013006
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a incidence $7 D015994
- 650 _2
- $a osteoporotické fraktury $x epidemiologie $x etiologie $7 D058866
- 650 _2
- $a radius $x diagnostické zobrazování $7 D011884
- 650 _2
- $a rizikové faktory $7 D012307
- 650 _2
- $a časové faktory $7 D013997
- 650 _2
- $a počítačová rentgenová tomografie $x metody $7 D014057
- 650 _2
- $a Turnerův syndrom $x komplikace $x farmakoterapie $x patofyziologie $7 D014424
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Schönau, Eckhard $u Department of Pediatrics, University Hospital Cologne and Cologne University, Cologne, Germany.
- 700 1_
- $a Lebl, Jan $u Department of Pediatrics, Second Medical Faculty, Charles University in Prague and Motol University Hospital, Prague, Czech Republic.
- 700 1_
- $a Willnecker, Johannes $u Stratec Medizintechnik GmbH, Pforzheim, Germany.
- 700 1_
- $a Hlavka, Zdenek $u Department of Probability and Mathematical Statistics, Faculty of Mathematics and Physics, Charles University in Prague, Prague, Czech Republic.
- 700 1_
- $a Sumnik, Zdenek $u Department of Pediatrics, Second Medical Faculty, Charles University in Prague and Motol University Hospital, Prague, Czech Republic.
- 773 0_
- $w MED00002582 $t The Journal of clinical endocrinology and metabolism $x 1945-7197 $g Roč. 103, č. 3 (2018), s. 1188-1197
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/29300907 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20180709 $b ABA008
- 991 __
- $a 20180718112732 $b ABA008
- 999 __
- $a ok $b bmc $g 1316532 $s 1021322
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2018 $b 103 $c 3 $d 1188-1197 $i 1945-7197 $m The Journal of clinical endocrinology and metabolism $n J Clin Endocrinol Metab $x MED00002582
- LZP __
- $a Pubmed-20180709