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Parathyroid Carcinoma in Patients that Have Undergone Surgery for Primary Hyperparathyroidism

P. Libánský, S. Adámek, P. Broulík, M. Fialová, J. Kubinyi, R. Lischke, O. Naňka, P. Pafko, J. Šedý, V. Bobek,

. 2017 ; 31 (5) : 925-930.

Language English Country Greece

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc18024674

BACKGROUND/AIM: Parathyroid carcinoma is a rare clinical entity, which represents one of the main reasons, why surgery should be performed in specialized centres. Preoperatively, it is very difficult to distinguish between benign and malignant hyperparathyroidism. PATIENTS AND METHODS: During the years 1996-2016, we performed 2,220 operations in 2,075 patients with a diagnosis of primary hyperparathyroidism. RESULTS: Among these 2,220 operations, there were 16 operations for parathyroid carcinoma. These 16 operations, including reoperations, were performed in four patients. Two patients had no reoperation, but another 2 patients required 14 reoperations in total. Parathyroid carcinoma was described in 0.2% of all patients with a diagnosis of primary hyperparathyroidism. The number of operations was 0.73% of all operations of primary hyperparathyroidism in years 1996-2016. CONCLUSION: Prognosis of parathyroid carcinoma is quite favourable, patients evidence a long-term survival rate after the primary operation. However, every reoperation increases the number of possible complications, including recurrent laryngeal nerve injury.

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$a Adámek, Svatopluk $u Third Department of Surgery, First Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic.
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$a Broulík, Petr $u Third Department of Medicine, Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic.
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$a Fialová, Martina $u Third Department of Surgery, First Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic.
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$a Kubinyi, Josef $u Institute of Nuclear Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic.
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$a Lischke, Robert $u Third Department of Surgery, First Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic.
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$a Naňka, Ondřej $u Institute of Anatomy, First Faculty of Medicine, Charles University, Prague, Czech Republic.
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$a Pafko, Pavel $u Third Department of Surgery, First Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic.
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$a Šedý, Jiří $u Department of Anatomy, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
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$a Bobek, Vladimír $u Third Department of Surgery, First Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic vbobek@centrum.cz. Department of Laboratory Genetics, University Hospital Kralovske Vinohrady, Prague, Czech Republic. Department of Thoracic Surgery, Masaryk's Hospital in Usti nad Labem, Labem, Czech Republic. Department of Histology and Embryology, Wroclaw Medical University, Wroclaw, Poland.
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