• Je něco špatně v tomto záznamu ?

Arbitrariness is not enough: towards a functional approach to the genetic code

Ľ. Lacková, V. Matlach, D. Faltýnek,

. 2017 ; 136 (3-4) : 187-191. [pub] 20170509

Jazyk angličtina Země Německo

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc18025036
E-zdroje Online Plný text

NLK ProQuest Central od 2000-03-01 do Před 1 rokem
Medline Complete (EBSCOhost) od 2002-05-01 do Před 1 rokem

Arbitrariness in the genetic code is one of the main reasons for a linguistic approach to molecular biology: the genetic code is usually understood as an arbitrary relation between amino acids and nucleobases. However, from a semiotic point of view, arbitrariness should not be the only condition for definition of a code, consequently it is not completely correct to talk about "code" in this case. Yet we suppose that there exist a code in the process of protein synthesis, but on a higher level than the nucleic bases chains. Semiotically, a code should be always associated with a function and we propose to define the genetic code not only relationally (in basis of relation between nucleobases and amino acids) but also in terms of function (function of a protein as meaning of the code). Even if the functional definition of meaning in the genetic code has been discussed in the field of biosemiotics, its further implications have not been considered. In fact, if the function of a protein represents the meaning of the genetic code (the sign's object), then it is crucial to reconsider the notion of its expression (the sign) as well. In our contribution, we will show that the actual model of the genetic code is not the only possible and we will propose a more appropriate model from a semiotic point of view.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc18025036
003      
CZ-PrNML
005      
20180717090930.0
007      
ta
008      
180709s2017 gw f 000 0|eng||
009      
AR
024    7_
$a 10.1007/s12064-017-0246-1 $2 doi
035    __
$a (PubMed)28488159
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a gw
100    1_
$a Lacková, Ľudmila $u Department of General Linguistics, Palacký University, Křížkovského 14, 771 47, Olomouc, Czech Republic. ludmila.lackova01@upol.cz.
245    10
$a Arbitrariness is not enough: towards a functional approach to the genetic code / $c Ľ. Lacková, V. Matlach, D. Faltýnek,
520    9_
$a Arbitrariness in the genetic code is one of the main reasons for a linguistic approach to molecular biology: the genetic code is usually understood as an arbitrary relation between amino acids and nucleobases. However, from a semiotic point of view, arbitrariness should not be the only condition for definition of a code, consequently it is not completely correct to talk about "code" in this case. Yet we suppose that there exist a code in the process of protein synthesis, but on a higher level than the nucleic bases chains. Semiotically, a code should be always associated with a function and we propose to define the genetic code not only relationally (in basis of relation between nucleobases and amino acids) but also in terms of function (function of a protein as meaning of the code). Even if the functional definition of meaning in the genetic code has been discussed in the field of biosemiotics, its further implications have not been considered. In fact, if the function of a protein represents the meaning of the genetic code (the sign's object), then it is crucial to reconsider the notion of its expression (the sign) as well. In our contribution, we will show that the actual model of the genetic code is not the only possible and we will propose a more appropriate model from a semiotic point of view.
650    _2
$a aminokyseliny $x chemie $7 D000596
650    _2
$a DNA $x chemie $7 D004247
650    12
$a genetický kód $7 D005815
650    _2
$a histony $x chemie $7 D006657
650    _2
$a modely genetické $7 D008957
650    _2
$a teoretické modely $7 D008962
650    _2
$a nukleotidy $x genetika $7 D009711
650    _2
$a bodová mutace $7 D017354
650    _2
$a sbalování proteinů $7 D017510
650    _2
$a RNA $x chemie $7 D012313
655    _2
$a časopisecké články $7 D016428
700    1_
$a Matlach, Vladimír $u Department of General Linguistics, Palacký University, Křížkovského 14, 771 47, Olomouc, Czech Republic.
700    1_
$a Faltýnek, Dan $u Department of General Linguistics, Palacký University, Křížkovského 14, 771 47, Olomouc, Czech Republic.
773    0_
$w MED00005118 $t Theory in biosciences Theorie in den Biowissenschaften $x 1611-7530 $g Roč. 136, č. 3-4 (2017), s. 187-191
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28488159 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20180709 $b ABA008
991    __
$a 20180717091229 $b ABA008
999    __
$a ok $b bmc $g 1317167 $s 1021957
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 136 $c 3-4 $d 187-191 $e 20170509 $i 1611-7530 $m Theory in biosciences $n Theory Biosci $x MED00005118
LZP    __
$a Pubmed-20180709

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...