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Analysis of Streptomyces coelicolor M145 genes SCO4164 and SCO5854 encoding putative rhodaneses
T. Gren, B. Ostash, V. Babiy, I. Rokytskyy, V. Fedorenko,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
- MeSH
- anthrachinony metabolismus MeSH
- antibakteriální látky metabolismus MeSH
- bakteriální proteiny genetika metabolismus MeSH
- kultivační média metabolismus MeSH
- sekundární metabolismus MeSH
- sírany metabolismus MeSH
- Streptomyces coelicolor enzymologie genetika růst a vývoj metabolismus MeSH
- thiosulfátsulfurtransferasa genetika metabolismus MeSH
- Publikační typ
- časopisecké články MeSH
Streptomyces coelicolor genome carries two apparently paralogous genes, SCO4164 and SCO5854, that encode putative thiosulfate sulfurtransferases (rhodaneses). These genes (and their presumed translation products) are highly conserved and widely distributed across actinobacterial genomes. The SCO4164 knockout strain was unable to grow on minimal media with either sulfate or sulfite as the sole sulfur source. The SCO5854 mutant had no growth defects in the presence of various sulfur sources; however, it produced significantly less amounts of actinorhodin. Furthermore, we discuss possible links between basic interconversions of inorganic sulfur species and secondary metabolism in S. coelicolor.
Citace poskytuje Crossref.org
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- $a Gren, Tetiana $u Department of Genetics and Biotechnology, Ivan Franko National University of Lviv, 4 Hrushevskoho St, Lviv, 79005, Ukraine. Microbial Genomics and Biotechnology, Center for Biotechnology, Bielefeld University, Universitätsstraße 27, 33615, Bielefeld, Germany.
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