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Therapeutic potential of vitamin E and its derivatives in traumatic brain injury-associated dementia
J. Dobrovolny, M. Smrcka, J. Bienertova-Vasku,
Language English Country Italy
Document type Journal Article, Review
NLK
ProQuest Central
from 2000-01-01 to 1 year ago
Medline Complete (EBSCOhost)
from 2000-02-01 to 1 year ago
Health & Medicine (ProQuest)
from 2000-01-01 to 1 year ago
Family Health Database (ProQuest)
from 2000-01-01 to 1 year ago
Psychology Database (ProQuest)
from 2000-01-01 to 1 year ago
- MeSH
- Antioxidants administration & dosage MeSH
- Dementia etiology prevention & control MeSH
- Humans MeSH
- Dietary Supplements MeSH
- Brain Injuries, Traumatic complications diet therapy psychology MeSH
- Vitamin E administration & dosage analogs & derivatives MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Traumatic brain injury is one of the most common causes for intervention in neurosurgery. Apart from its acute consequence, it can represent a further burden on individuals as well as society by being associated with significant comorbidity-mainly early-onset dementia. Oxidative stress is one of the crucial mechanisms conferring the damage to nervous tissue, and it is believed it could be, to some extent, influenced by dietary composition, largely by antioxidants contained in the diet. Under stressful conditions, cell-derived reactive oxygen species in the brain can induce the formation of lipid peroxides and the shifting of redox homeostasis. This review discusses the potential of vitamin E as a potent antioxidant and its derived molecules, including vitamin E-based lazaroids, in traumatic brain injury, summarizing the current state of knowledge of its role in TBI-associated dementia.
References provided by Crossref.org
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- $a Dobrovolny, Jan $u Clinic of Neurosurgery, University Hospital Brno, Jihlavská 2, 625 00, Brno, Czech Republic.
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- $a Therapeutic potential of vitamin E and its derivatives in traumatic brain injury-associated dementia / $c J. Dobrovolny, M. Smrcka, J. Bienertova-Vasku,
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- $a Traumatic brain injury is one of the most common causes for intervention in neurosurgery. Apart from its acute consequence, it can represent a further burden on individuals as well as society by being associated with significant comorbidity-mainly early-onset dementia. Oxidative stress is one of the crucial mechanisms conferring the damage to nervous tissue, and it is believed it could be, to some extent, influenced by dietary composition, largely by antioxidants contained in the diet. Under stressful conditions, cell-derived reactive oxygen species in the brain can induce the formation of lipid peroxides and the shifting of redox homeostasis. This review discusses the potential of vitamin E as a potent antioxidant and its derived molecules, including vitamin E-based lazaroids, in traumatic brain injury, summarizing the current state of knowledge of its role in TBI-associated dementia.
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- $a Smrcka, Martin $u Clinic of Neurosurgery, University Hospital Brno, Jihlavská 2, 625 00, Brno, Czech Republic.
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- $a Bienertova-Vasku, Julie $u Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, Building A18, 625 00, Brno, Czech Republic. jbienert@med.muni.cz. Research Centre for Toxic Compounds in the Environment, Faculty of Sciences, Masaryk University, Kamenice A29, 625 00, Brno, Czech Republic. jbienert@med.muni.cz.
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