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Therapeutic potential of vitamin E and its derivatives in traumatic brain injury-associated dementia
J. Dobrovolny, M. Smrcka, J. Bienertova-Vasku,
Jazyk angličtina Země Itálie
Typ dokumentu časopisecké články, přehledy
NLK
ProQuest Central
od 2000-01-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2000-02-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Family Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
Psychology Database (ProQuest)
od 2000-01-01 do Před 1 rokem
- MeSH
- antioxidancia aplikace a dávkování MeSH
- demence etiologie prevence a kontrola MeSH
- lidé MeSH
- potravní doplňky MeSH
- traumatické poranění mozku komplikace dietoterapie psychologie MeSH
- vitamin E aplikace a dávkování analogy a deriváty MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Traumatic brain injury is one of the most common causes for intervention in neurosurgery. Apart from its acute consequence, it can represent a further burden on individuals as well as society by being associated with significant comorbidity-mainly early-onset dementia. Oxidative stress is one of the crucial mechanisms conferring the damage to nervous tissue, and it is believed it could be, to some extent, influenced by dietary composition, largely by antioxidants contained in the diet. Under stressful conditions, cell-derived reactive oxygen species in the brain can induce the formation of lipid peroxides and the shifting of redox homeostasis. This review discusses the potential of vitamin E as a potent antioxidant and its derived molecules, including vitamin E-based lazaroids, in traumatic brain injury, summarizing the current state of knowledge of its role in TBI-associated dementia.
Citace poskytuje Crossref.org
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- $a Dobrovolny, Jan $u Clinic of Neurosurgery, University Hospital Brno, Jihlavská 2, 625 00, Brno, Czech Republic.
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- $a Therapeutic potential of vitamin E and its derivatives in traumatic brain injury-associated dementia / $c J. Dobrovolny, M. Smrcka, J. Bienertova-Vasku,
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- $a Traumatic brain injury is one of the most common causes for intervention in neurosurgery. Apart from its acute consequence, it can represent a further burden on individuals as well as society by being associated with significant comorbidity-mainly early-onset dementia. Oxidative stress is one of the crucial mechanisms conferring the damage to nervous tissue, and it is believed it could be, to some extent, influenced by dietary composition, largely by antioxidants contained in the diet. Under stressful conditions, cell-derived reactive oxygen species in the brain can induce the formation of lipid peroxides and the shifting of redox homeostasis. This review discusses the potential of vitamin E as a potent antioxidant and its derived molecules, including vitamin E-based lazaroids, in traumatic brain injury, summarizing the current state of knowledge of its role in TBI-associated dementia.
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- $a Smrcka, Martin $u Clinic of Neurosurgery, University Hospital Brno, Jihlavská 2, 625 00, Brno, Czech Republic.
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- $a Bienertova-Vasku, Julie $u Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, Building A18, 625 00, Brno, Czech Republic. jbienert@med.muni.cz. Research Centre for Toxic Compounds in the Environment, Faculty of Sciences, Masaryk University, Kamenice A29, 625 00, Brno, Czech Republic. jbienert@med.muni.cz.
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- $w MED00005781 $t Neurological sciences official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology $x 1590-3478 $g Roč. 39, č. 6 (2018), s. 989-998
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