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Dioxin-like compounds bioavailability and genotoxicity assessment in the Gulf of Follonica, Tuscany (Northern Tyrrhenian Sea)

P. Guidi, S. Corsolini, M. Bernardeschi, L. Rocco, M. Nigro, D. Baroni, F. Mottola, V. Scarcelli, M. Santonastaso, A. Falleni, C. Della Torre, I. Corsi, K. Pozo, G. Frenzilli,

. 2018 ; 126 (-) : 467-472. [pub] 20171205

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc18033332

The Gulf of Follonica (Italy) is impacted by the chemical pollution from ancient mining activity and present industrial processes. This study was aimed to determine the bioavailability of dioxin-like compounds (DLCs) in coastal marine environment and to assess the genotoxic potential of waste waters entering the sea from an industrial canal. Moderately high levels of DCLs compounds (∑ PCDDs + PCDFs 2.18–29.00 pg/g dry wt) were detected in Mytilus galloprovincialis transplanted near the waste waters canal and their corresponding Toxic Equivalents (TEQs) calculated. In situ exposed mussels did not show any genotoxic effect (by Comet and Micronucleus assay). Otherwise, laboratory exposure to canal waters exhibited a reduced genomic template stability (by RAPD-PCR assay) but not DNA or chromosomal damage. Our data reveal the need to focus on the levels and distribution of DLCs in edible species from the study area considering their potential transfer to humans through the consumption of sea food.

Citace poskytuje Crossref.org

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$a Guidi, Patrizia $u Department of Clinical and Experimental Medicine - Section of Applied Biology and Genetics, University of Pisa, Pisa, Italy.
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$a The Gulf of Follonica (Italy) is impacted by the chemical pollution from ancient mining activity and present industrial processes. This study was aimed to determine the bioavailability of dioxin-like compounds (DLCs) in coastal marine environment and to assess the genotoxic potential of waste waters entering the sea from an industrial canal. Moderately high levels of DCLs compounds (∑ PCDDs + PCDFs 2.18–29.00 pg/g dry wt) were detected in Mytilus galloprovincialis transplanted near the waste waters canal and their corresponding Toxic Equivalents (TEQs) calculated. In situ exposed mussels did not show any genotoxic effect (by Comet and Micronucleus assay). Otherwise, laboratory exposure to canal waters exhibited a reduced genomic template stability (by RAPD-PCR assay) but not DNA or chromosomal damage. Our data reveal the need to focus on the levels and distribution of DLCs in edible species from the study area considering their potential transfer to humans through the consumption of sea food.
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$a Corsolini, Simonetta $u Department of Physical, Earth and Environmental Sciences, University of Siena, Siena, Italy.
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$a Bernardeschi, Margherita $u Department of Clinical and Experimental Medicine - Section of Applied Biology and Genetics, University of Pisa, Pisa, Italy.
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$a Rocco, Lucia $u Department of Environmental, Biological and Pharmaceutical, Sciences and Technologies, Second University of Naples, Caserta, Italy.
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$a Nigro, Marco $u Department of Clinical and Experimental Medicine - Section of Applied Biology and Genetics, University of Pisa, Pisa, Italy. Electronic address: marco.nigro@med.unipi.it.
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$a Baroni, Davide $u Department of Physical, Earth and Environmental Sciences, University of Siena, Siena, Italy.
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$a Mottola, Filomena $u Department of Environmental, Biological and Pharmaceutical, Sciences and Technologies, Second University of Naples, Caserta, Italy.
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$a Scarcelli, Vittoria $u Department of Clinical and Experimental Medicine - Section of Applied Biology and Genetics, University of Pisa, Pisa, Italy.
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$a Santonastaso, Marianna $u Department of Environmental, Biological and Pharmaceutical, Sciences and Technologies, Second University of Naples, Caserta, Italy.
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$a Falleni, Alessandra $u Department of Clinical and Experimental Medicine - Section of Applied Biology and Genetics, University of Pisa, Pisa, Italy.
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$a Della Torre, Camilla $u Department of Physical, Earth and Environmental Sciences, University of Siena, Siena, Italy; Department of Biosciences, University of Milan, Milan, Italy.
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$a Corsi, Ilaria $u Department of Physical, Earth and Environmental Sciences, University of Siena, Siena, Italy.
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$a Pozo, Karla $u Department of Physical, Earth and Environmental Sciences, University of Siena, Siena, Italy; Masaryk University, Research Centre for Toxic Compounds in the Environment, Brno, Czech Republic; Facultad de Ciencias, Universidad Católica Santísima Concepción, Concepción, Chile.
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$a Frenzilli, Giada $u Department of Clinical and Experimental Medicine - Section of Applied Biology and Genetics, University of Pisa, Pisa, Italy.
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