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Adipokines in neurovascular diseases
R. Opatrilova, M. Caprnda, P. Kubatka, V. Valentova, S. Uramova, V. Nosal, L. Gaspar, L. Zachar, I. Mozos, D. Petrovic, J. Dragasek, S. Filipova, D. Büsselberg, A. Zulli, L. Rodrigo, P. Kruzliak, V. Krasnik,
Jazyk angličtina Země Francie
Typ dokumentu časopisecké články, přehledy
NLK
Directory of Open Access Journals
od 2018
Elsevier Open Access Journals
od 2018-12-01
ROAD: Directory of Open Access Scholarly Resources
od 2002
- MeSH
- adipokiny metabolismus MeSH
- ateroskleróza metabolismus MeSH
- cévní mozková příhoda metabolismus MeSH
- ischemie metabolismus MeSH
- lidé MeSH
- nemoci cév metabolismus MeSH
- nemoci nervového systému metabolismus MeSH
- tuková tkáň metabolismus MeSH
- zánět metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Adipose tissue is now described as an endocrine organ secreting a number of adipokines contributing to the development of inflammation and metabolic imbalance, but also endothelial dysfunction, vascular remodeling, atherosclerosis, and ischemic stroke. Leptin, adiponectin, and resistin are the most studied adipokines which play important roles in the regulation of cardiovascular homeostasis. Leptin and adiponectin mediate both proatherogenic and antiatherogenic responses. Leptin and adiponectin have been linked to the development of coronary heart disease and may be involved in the underlying biological mechanism of ischemic stroke. Resistin, a pro-inflammatory cytokine, is predictive of atherosclerosis and poor clinical outcomes in patients with coronary artery disease and ischemic stroke. The changes in serum levels of novel adipokines apelin, visfatin are also associated with acute ischemic stroke. These adipokines have been proposed as potential prognostic biomarkers of cardiovascular mortality/morbidity and therapeutic targets in patients with cardiometabolic diseases. In this article, we summarize the biologic role of the adipokines and discuss the link between dysfunctional adipose tissue and metabolic/inflammation imbalance, consequently endothelial damage, progression of atherosclerotic disease, and the occurrence of ischemic stroke.
Department of Functional Sciences Victor Babes University of Medicine and Pharmacy Timisoara Romania
Faculty of Medicine University of Oviedo Central University Hospital of Asturias Oviedo Spain
Institute of Histology and Embryology Faculty of Medicine University of Ljubljana Ljubljana Slovenia
Weill Cornell Medicine in Qatar Qatar Foundation Education City Doha Qatar
Citace poskytuje Crossref.org
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- $a Opatrilova, Radka $u Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
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- $a Adipose tissue is now described as an endocrine organ secreting a number of adipokines contributing to the development of inflammation and metabolic imbalance, but also endothelial dysfunction, vascular remodeling, atherosclerosis, and ischemic stroke. Leptin, adiponectin, and resistin are the most studied adipokines which play important roles in the regulation of cardiovascular homeostasis. Leptin and adiponectin mediate both proatherogenic and antiatherogenic responses. Leptin and adiponectin have been linked to the development of coronary heart disease and may be involved in the underlying biological mechanism of ischemic stroke. Resistin, a pro-inflammatory cytokine, is predictive of atherosclerosis and poor clinical outcomes in patients with coronary artery disease and ischemic stroke. The changes in serum levels of novel adipokines apelin, visfatin are also associated with acute ischemic stroke. These adipokines have been proposed as potential prognostic biomarkers of cardiovascular mortality/morbidity and therapeutic targets in patients with cardiometabolic diseases. In this article, we summarize the biologic role of the adipokines and discuss the link between dysfunctional adipose tissue and metabolic/inflammation imbalance, consequently endothelial damage, progression of atherosclerotic disease, and the occurrence of ischemic stroke.
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- $a Caprnda, Martin $u 1st Department of Internal Medicine, Faculty of Medicine, Comenius University in Bratislava and University Hospital, Bratislava, Slovakia.
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- $a Krasnik, Vladimir $u Department of Ophthalmology, Faculty of Medicine, Comenius University in Bratislava and University Hospital, Bratislava, Slovakia.
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