-
Je něco špatně v tomto záznamu ?
Impairment of neural coordination in hippocampal neuronal ensembles after a psychotomimetic dose of dizocilpine
E. Szczurowska, N. Ahuja, P. Jiruška, E. Kelemen, A. Stuchlík,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
- MeSH
- akční potenciály účinky léků fyziologie MeSH
- dizocilpinmaleát farmakologie MeSH
- hipokampus účinky léků patofyziologie MeSH
- mikroelektrody MeSH
- neurony účinky léků fyziologie MeSH
- potkani Long-Evans MeSH
- psychotropní léky farmakologie MeSH
- theta rytmus EEG účinky léků fyziologie MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
The discoordination hypothesis of schizophrenia posits discoordination of neural activity as the central mechanism that underlies some psychotic symptoms (including 'hallmark' cognitive symptoms) of schizophrenia. To test this proposition, we studied the activity of hippocampal neurons in urethane anesthetized Long Evans rats after 0.15mg/kg dizocilpine (MK-801), an N-Methyl-d-aspartate (NMDA) glutamate receptor antagonist, which can cause psychotic symptoms in humans and cognitive control impairments in animals. We observed that MK-801 altered the temporal coordination, but not rate, of neuronal firing. Coactivation between neurons increased, driven primarily by increased coincident firing of cell pairs that did not originally fire together before MK-801 injection. Increased pairwise coactivation manifested as disorganized discharge on the level of neuronal ensembles, which in turn could lead to disorganization in information processing. Disorganization of neuronal activity after a psychotomimetic dose of MK-801 supports the discoordination hypothesis of psychosis.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc18033711
- 003
- CZ-PrNML
- 005
- 20181012100502.0
- 007
- ta
- 008
- 181008s2018 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.pnpbp.2017.09.013 $2 doi
- 035 __
- $a (PubMed)28935586
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Szczurowska, Ewa $u National Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech Republic.
- 245 10
- $a Impairment of neural coordination in hippocampal neuronal ensembles after a psychotomimetic dose of dizocilpine / $c E. Szczurowska, N. Ahuja, P. Jiruška, E. Kelemen, A. Stuchlík,
- 520 9_
- $a The discoordination hypothesis of schizophrenia posits discoordination of neural activity as the central mechanism that underlies some psychotic symptoms (including 'hallmark' cognitive symptoms) of schizophrenia. To test this proposition, we studied the activity of hippocampal neurons in urethane anesthetized Long Evans rats after 0.15mg/kg dizocilpine (MK-801), an N-Methyl-d-aspartate (NMDA) glutamate receptor antagonist, which can cause psychotic symptoms in humans and cognitive control impairments in animals. We observed that MK-801 altered the temporal coordination, but not rate, of neuronal firing. Coactivation between neurons increased, driven primarily by increased coincident firing of cell pairs that did not originally fire together before MK-801 injection. Increased pairwise coactivation manifested as disorganized discharge on the level of neuronal ensembles, which in turn could lead to disorganization in information processing. Disorganization of neuronal activity after a psychotomimetic dose of MK-801 supports the discoordination hypothesis of psychosis.
- 650 _2
- $a akční potenciály $x účinky léků $x fyziologie $7 D000200
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a dizocilpinmaleát $x farmakologie $7 D016291
- 650 _2
- $a hipokampus $x účinky léků $x patofyziologie $7 D006624
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a mikroelektrody $7 D008839
- 650 _2
- $a neurony $x účinky léků $x fyziologie $7 D009474
- 650 _2
- $a psychotropní léky $x farmakologie $7 D011619
- 650 _2
- $a potkani Long-Evans $7 D020318
- 650 _2
- $a theta rytmus EEG $x účinky léků $x fyziologie $7 D013826
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Ahuja, Nikhil $u Department of Neurophysiology of Memory and Institute of Physiology, Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech Republic.
- 700 1_
- $a Jiruška, Přemysl $u Department of Developmental Epileptology, Institute of Physiology, Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech Republic.
- 700 1_
- $a Kelemen, Eduard $u National Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech Republic. Electronic address: Eduard.Kelemen@nudz.cz.
- 700 1_
- $a Stuchlík, Aleš $u Department of Neurophysiology of Memory and Institute of Physiology, Czech Academy of Sciences, Vídeňská 1083, 142 20 Prague, Czech Republic. Electronic address: Ales.Stuchlik@fgu.cas.cz.
- 773 0_
- $w MED00003930 $t Progress in neuro-psychopharmacology & biological psychiatry $x 1878-4216 $g Roč. 81, č. - (2018), s. 275-283
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/28935586 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20181008 $b ABA008
- 991 __
- $a 20181012100954 $b ABA008
- 999 __
- $a ok $b bmc $g 1340264 $s 1030705
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2018 $b 81 $c - $d 275-283 $e 20170919 $i 1878-4216 $m Progress in neuro-psychopharmacology & biological psychiatry $n Prog Neuropsychopharmacol Biol Psychiatry $x MED00003930
- LZP __
- $a Pubmed-20181008
