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Clinical and laboratory predictors of Infectious Complications in patients after Out-of-Hospital Cardiac Arrest
J. Kroupa, J. Knot, J. Ulman, F. Bednar, A. Dohnalova, Z. Motovska,
Language English Country United States
Document type Journal Article, Observational Study, Research Support, Non-U.S. Gov't
NLK
ProQuest Central
from 2003-03-01 to 2 months ago
Nursing & Allied Health Database (ProQuest)
from 2003-03-01 to 2 months ago
Health & Medicine (ProQuest)
from 2003-03-01 to 2 months ago
- MeSH
- Anti-Bacterial Agents therapeutic use MeSH
- Antibiotic Prophylaxis statistics & numerical data MeSH
- C-Reactive Protein metabolism MeSH
- Time-to-Treatment MeSH
- Length of Stay statistics & numerical data MeSH
- ST Elevation Myocardial Infarction complications therapy MeSH
- Respiratory Tract Infections complications prevention & control MeSH
- Calcitonin metabolism MeSH
- Coronary Care Units statistics & numerical data MeSH
- Middle Aged MeSH
- Humans MeSH
- Unnecessary Procedures MeSH
- Sepsis complications prevention & control MeSH
- Hypothermia, Induced methods MeSH
- Respiration, Artificial statistics & numerical data MeSH
- Emergency Service, Hospital statistics & numerical data MeSH
- Out-of-Hospital Cardiac Arrest complications therapy MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Observational Study MeSH
- Research Support, Non-U.S. Gov't MeSH
PURPOSE: Identification of clinical and laboratory predictors related to Infectious Complications (ICs) in patients after Out-of-Hospital Cardiac Arrest (OHCA). METHODS: Patients, aged >18, after an OHCA between 9/2013 and 11/2015, surviving >24h, were studied. RESULTS: Study group consisted of 42 patients (mean age 63.4years, 88.1% men). Forty percent of patients had IC; lower respiratory tract infections were most common (87.5% of cases). ICs were more common in patients receiving Targeted Temperature Management (50% vs. 10%; p=0.032). Antibiotics were used in 85.7% of patients. The mean time to therapy initiation was 9.6 (SD 7.1) hours after admission. The mean course of treatment was 9.0 (SD 6.2) days. Fifty-three percent of patients receiving early antibiotic treatment didn't have IC. Initial antibiotic therapy was changed more often in patients with IC (75% vs. 38.9%; p=0.045). C-Reactive Protein, Procalcitonin, Troponin and White Blood Cell count values were higher in patients with IC. CONCLUSION: Early initiated antibiotic treatment is overused in patients after OHCA. This practice is associated with necessitating antibiotic change in the majority of patients with IC. Assessment of clinical and laboratory parameters in the first days after OHCA increases the likelihood of appropriate ATB therapy.
Cardiocenter 3rd Faculty of Medicine Charles University Prague Czech Republic
Institute of Physiology 1st Faculty of Medicine Charles University Prague Czech Republic
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- $a PURPOSE: Identification of clinical and laboratory predictors related to Infectious Complications (ICs) in patients after Out-of-Hospital Cardiac Arrest (OHCA). METHODS: Patients, aged >18, after an OHCA between 9/2013 and 11/2015, surviving >24h, were studied. RESULTS: Study group consisted of 42 patients (mean age 63.4years, 88.1% men). Forty percent of patients had IC; lower respiratory tract infections were most common (87.5% of cases). ICs were more common in patients receiving Targeted Temperature Management (50% vs. 10%; p=0.032). Antibiotics were used in 85.7% of patients. The mean time to therapy initiation was 9.6 (SD 7.1) hours after admission. The mean course of treatment was 9.0 (SD 6.2) days. Fifty-three percent of patients receiving early antibiotic treatment didn't have IC. Initial antibiotic therapy was changed more often in patients with IC (75% vs. 38.9%; p=0.045). C-Reactive Protein, Procalcitonin, Troponin and White Blood Cell count values were higher in patients with IC. CONCLUSION: Early initiated antibiotic treatment is overused in patients after OHCA. This practice is associated with necessitating antibiotic change in the majority of patients with IC. Assessment of clinical and laboratory parameters in the first days after OHCA increases the likelihood of appropriate ATB therapy.
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