-
Something wrong with this record ?
Trans-generational neurochemical modulation of methamphetamine in the adult brain of the Wistar rat
M. Fujáková-Lipski, D. Kaping, J. Šírová, J. Horáček, T. Páleníček, P. Zach, J. Klaschka, P. Kačer, K. Syslová, M. Vrajová, V. Bubenikova-Valešová, C. Beste, R. Šlamberová,
Language English Country Germany
Document type Journal Article
NLK
ProQuest Central
from 2002-01-01 to 1 year ago
Medline Complete (EBSCOhost)
from 2000-01-01 to 1 year ago
Health & Medicine (ProQuest)
from 2002-01-01 to 1 year ago
Public Health Database (ProQuest)
from 2002-01-01 to 1 year ago
- MeSH
- Dopamine metabolism MeSH
- gamma-Aminobutyric Acid MeSH
- Glutamic Acid metabolism MeSH
- Methamphetamine administration & dosage pharmacokinetics toxicity MeSH
- Brain drug effects metabolism MeSH
- Rats, Wistar MeSH
- Serotonin metabolism MeSH
- Pregnancy MeSH
- Prenatal Exposure Delayed Effects * MeSH
- Animals MeSH
- Check Tag
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
Chronic methamphetamine (METH) abuse has been shown to elicit strong neurotoxic effects. Yet, with an increasing number of children born to METH abusing mothers maturing into adulthood, one important question is how far do the neurotoxic effects of METH alter various neurotransmitter systems in the adult METH-exposed offspring. The purpose of this study was to investigate long-term trans-generational neurochemical changes, following prenatal METH exposure, in the adult Wistar rat brain. METH or saline (SAL-control animals) was administered to pregnant dams throughout the entire gestation period (G0-G22). At postnatal day 90, dopamine, serotonin, glutamate and GABA were measured in the adult brain before (baseline) and after a METH re-administration using in vivo microdialysis and liquid chromatography/mass spectrometry. The results show that METH-exposure increased basal levels of monoamines and glutamate, but decreased GABA levels in all measured brain regions. Acute challenge with METH injection in the METH-exposed group induced a lower increase in the monoamine system relative to the increase in the GABAergic and glutamatergic system. The data show that prenatal METH exposure has strong effects on the monoaminergic, GABAergic and glutamatergic system even when exposure to METH was limited to the prenatal phase. Toxicological effects of METH have therefore longer lasting effects as currently considered and seem to affect the excitatory-inhibitory balance in the brain having strong implications for cognitive and behavioral functioning.
Department of Anatomy 3rd Faculty of Medicine Charles University Prague Czech Republic
Department of Organic Technology University of Chemistry and Technology Prague Czech Republic
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc18033911
- 003
- CZ-PrNML
- 005
- 20181022132157.0
- 007
- ta
- 008
- 181008s2017 gw f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1007/s00204-017-1969-y $2 doi
- 035 __
- $a (PubMed)28477265
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a gw
- 100 1_
- $a Fujáková-Lipski, Michaela $u National Institute of Mental Health, Klecany, Czech Republic. michaela.lipski@nudz.cz. Third Faculty of Medicine, Charles University, Prague, Czech Republic. michaela.lipski@nudz.cz.
- 245 10
- $a Trans-generational neurochemical modulation of methamphetamine in the adult brain of the Wistar rat / $c M. Fujáková-Lipski, D. Kaping, J. Šírová, J. Horáček, T. Páleníček, P. Zach, J. Klaschka, P. Kačer, K. Syslová, M. Vrajová, V. Bubenikova-Valešová, C. Beste, R. Šlamberová,
- 520 9_
- $a Chronic methamphetamine (METH) abuse has been shown to elicit strong neurotoxic effects. Yet, with an increasing number of children born to METH abusing mothers maturing into adulthood, one important question is how far do the neurotoxic effects of METH alter various neurotransmitter systems in the adult METH-exposed offspring. The purpose of this study was to investigate long-term trans-generational neurochemical changes, following prenatal METH exposure, in the adult Wistar rat brain. METH or saline (SAL-control animals) was administered to pregnant dams throughout the entire gestation period (G0-G22). At postnatal day 90, dopamine, serotonin, glutamate and GABA were measured in the adult brain before (baseline) and after a METH re-administration using in vivo microdialysis and liquid chromatography/mass spectrometry. The results show that METH-exposure increased basal levels of monoamines and glutamate, but decreased GABA levels in all measured brain regions. Acute challenge with METH injection in the METH-exposed group induced a lower increase in the monoamine system relative to the increase in the GABAergic and glutamatergic system. The data show that prenatal METH exposure has strong effects on the monoaminergic, GABAergic and glutamatergic system even when exposure to METH was limited to the prenatal phase. Toxicological effects of METH have therefore longer lasting effects as currently considered and seem to affect the excitatory-inhibitory balance in the brain having strong implications for cognitive and behavioral functioning.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a mozek $x účinky léků $x metabolismus $7 D001921
- 650 _2
- $a dopamin $x metabolismus $7 D004298
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a kyselina glutamová $x metabolismus $7 D018698
- 650 _2
- $a methamfetamin $x aplikace a dávkování $x farmakokinetika $x toxicita $7 D008694
- 650 _2
- $a těhotenství $7 D011247
- 650 12
- $a zpožděný efekt prenatální expozice $7 D011297
- 650 _2
- $a potkani Wistar $7 D017208
- 650 _2
- $a serotonin $x metabolismus $7 D012701
- 650 _2
- $a GABA $7 D005680
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Kaping, Daniel $u National Institute of Mental Health, Klecany, Czech Republic. daniel.kaping@nudz.cz. Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Dresden, Germany. daniel.kaping@nudz.cz.
- 700 1_
- $a Šírová, Jana $u National Institute of Mental Health, Klecany, Czech Republic. Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Dresden, Germany. Third Faculty of Medicine, Charles University, Prague, Czech Republic.
- 700 1_
- $a Horáček, Jiří $u National Institute of Mental Health, Klecany, Czech Republic.
- 700 1_
- $a Páleníček, Tomáš $u National Institute of Mental Health, Klecany, Czech Republic.
- 700 1_
- $a Zach, Petr $u Department of Anatomy, Third Faculty of Medicine, Charles University, Prague, Czech Republic.
- 700 1_
- $a Klaschka, Jan $u Department of Medical Informatics and Biostatistics, Institute of Computer Science, The Czech Academy of Sciences, Prague, Czech Republic.
- 700 1_
- $a Kačer, Petr $u National Institute of Mental Health, Klecany, Czech Republic.
- 700 1_
- $a Syslová, Kamila $u Department of Organic Technology, University of Chemistry and Technology, Prague, Czech Republic.
- 700 1_
- $a Vrajová, Monika $u National Institute of Mental Health, Klecany, Czech Republic.
- 700 1_
- $a Bubenikova-Valešová, Věra $u National Institute of Mental Health, Klecany, Czech Republic.
- 700 1_
- $a Beste, Christian $u National Institute of Mental Health, Klecany, Czech Republic. Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Dresden, Germany.
- 700 1_
- $a Šlamberová, Romana $u Department of Normal, Pathological and Clinical Physiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic.
- 773 0_
- $w MED00009265 $t Archives of toxicology $x 1432-0738 $g Roč. 91, č. 10 (2017), s. 3373-3384
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/28477265 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20181008 $b ABA008
- 991 __
- $a 20181022132703 $b ABA008
- 999 __
- $a ok $b bmc $g 1340342 $s 1030905
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2017 $b 91 $c 10 $d 3373-3384 $e 20170505 $i 1432-0738 $m Archives of toxicology $n Arch Toxicol $x MED00009265
- LZP __
- $a Pubmed-20181008
