Metabolic reprogramming of cancer cells is a common hallmark of malignant transformation. The preference for aerobic glycolysis over oxidative phosphorylation in tumors is a well-studied phenomenon known as the Warburg effect. Importantly, metabolic transformation of cancer cells also involves alterations in signaling cascades contributing to lipid metabolism, amino acid flux and synthesis, and utilization of ketone bodies. Also, redox regulation interacts with metabolic reprogramming during malignant transformation. Flavonoids, widely distributed phytochemicals in plants, exert various beneficial effects on human health through modulating molecular cascades altered in the pathological cancer phenotype. Recent evidence has identified numerous flavonoids as modulators of critical components of cancer metabolism and associated pathways interacting with metabolic cascades such as redox balance. Flavonoids affect lipid metabolism by regulating fatty acid synthase, redox balance by modulating nuclear factor-erythroid factor 2-related factor 2 (Nrf2) activity, or amino acid flux and synthesis by phosphoglycerate mutase 1. Here, we discuss recent preclinical evidence evaluating the impact of flavonoids on cancer metabolism, focusing on lipid and amino acid metabolic cascades, redox balance, and ketone bodies.

Biomedical Centre Martin Jessenius Faculty of Medicine in Martin Comenius University in Bratislava Martin Slovakia

Clinic of Obstetrics and Gynecology Jessenius Faculty of Medicine Comenius University in Bratislava 036 01 Martin Slovakia

Department of Anatomy Comenius University in Bratislava Martin Slovakia

Department of Internal Medicine Faculty of Medicine Comenius University and University Hospital Bratislava Slovakia

Department of Internal Medicine Faculty of Medicine Masaryk University and St Anne's University Hospital Brno Czech Republic; International Clinical Research Centre St Anne's University Hospital and Masaryk University Brno Czech Republic

Department of Medical Biology Jessenius Faculty of Medicine Comenius University in Bratislava Martin Slovakia

Department of Nutrition Faculty of Nursing and Professional Health Studies Slovak Medical University Bratislava Slovakia; Department of General Medicine Faculty of Medicine Slovak Medical University Bratislava Slovakia

Department of Pathophysiology Jessenius Faculty of Medicine Comenius University in Bratislava Martin Slovakia

Department of Surgery Faculty of Medicine Masaryk University and St Anne's University Hospital Brno Czech Republic

Department of Thoracic Surgery Medical University of Silesia Katowice Poland

Faculty of Health Sciences University of Ss Cyril and Methodius in Trnava Trnava Slovakia

Predictive Preventive Personalised Medicine Department of Radiation Oncology University Hospital Bonn Rheinische Friedrich Wilhelms Universität Bonn Bonn Germany

Weill Cornell Medicine Qatar Education City Qatar Foundation Doha Qatar

Citace poskytuje Crossref.org

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