V rokoch 2017 a 2018 boli publikované výsledky dvoch veľkých kardiovaskulárnych štúdií s inhibítormi pro-proteín konvertázy subtilizín-kexín typu 9 (PCSK9i), ktoré potvrdili klinické výhody ich použitia u pacientov s vysokým rizikom rozvoja kardiovaskulárnych ochorení podmienených aterosklerózou (Atherosclerosis-related Cardio-Vascular Disease - ASCVD). Súhrnná analýza výsledkov štúdie FOURIER (Further cardiovascular OUtcomes Research with PCSK9 Inhibition in subjects with Elevated Risk) s evolokumabom bola publikovaná v NEJM [1]. V marci 2018 po čas kongresu ACC (American College of Cardiology) v Orlande boli prezentované výsledky štúdie ODYSSEY Outcomes (Evaluation of Cardiovascular Outcomes after an Acute Coronary Syndrome during Treatment with Alirocumab) s alirokumabom [2,3]. Aj keď existuje množstvo otvorených otázok, výsledky obidvoch štúdií potvrdzujú, že ďalšie znižovanie LDL-cholesterolu (LDL-C) vedie k zníženiu reziduálneho rizika ASCVD u vysokorizikových pacientov a doslova menia hypotézu týkajúcu sa LDL-C "čím nižšie tým lepšie" na realitu a potrebu každodenného života. V klinickej praxi však pridanie PCSK9i musíme vždy dôkladne zvážiť. V sekundárnej prevencii v prvej línii ostáva intenzívna statínová liečba s ezetimibom súčasne so zmenou životného štýlu. PCSK9i pridávame pacientom, u ktorých pretrváva LDL-C ≥1,8 mmol/l.

In the years 2017 and 2018, the results of two large cardiovascular trials with inhibitors of pro-protein convertase subtilisin-kexin type 9 (PCSK9i) were published and confirmed the clinical benefits of their use in patients at high risk of developing atherosclerosis-related cardiovascular disease (ASCVD). A summary analysis of FOURIER (Evolutionary Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk) study was published in NEJM [1]. In March 2018, during the ACC Congress in Orlando, the results of the ODYSSEY Outcomes Study (Assessment of Cardiovascular Outcomes after an Acute Coronary Syndrome during Treatment with Alirocumab) were presented [2,3]. Although there are a number of open questions, the results of the trials confirm that further reduction of LDL-C leads to a reduction in the residual risk of ASCVD in high-risk patients and changes the hypothesis on LDL-C "the lower is better" to reality and the need for everyday life. In clinical practice, however, we must always carefully consider adding PCSK9i. In secondary prevention in the first line intensive statin treatment with ezetimibe and lifestyle changes remains. PCSK9i is added to patients with LDL-C ≥ 1.8 mmol/l.

Metabol KLINIK s r o Bratislava

Open questions from cardiovascular studies FOURIER and ODYSSEY Outcomes

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