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The effect of ethylene oxide sterilization on electrospun vascular grafts made from biodegradable polyesters
J. Horakova, P. Mikes, A. Saman, V. Jencova, A. Klapstova, T. Svarcova, M. Ackermann, V. Novotny, T. Suchy, D. Lukas,
Materials science & engineering. C, Materials for biological applications.
2018 ;
92 (-) :
132-142.
[pub] 20180627
Language English Country Netherlands
Document type Journal Article
Persistent link
https://www.medvik.cz/link/bmc19000393
- MeSH
- Biocompatible Materials chemistry metabolism pharmacology MeSH
- Cell Line MeSH
- Blood Vessel Prosthesis MeSH
- Ethylene Oxide chemistry pharmacology MeSH
- Microscopy, Electron, Scanning MeSH
- Elastic Modulus MeSH
- Mice MeSH
- Nanofibers chemistry MeSH
- Tensile Strength MeSH
- Polyesters chemistry metabolism MeSH
- Sterilization MeSH
- Cell Survival drug effects MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
The study describes the detailed examination of the effect of ethylene oxide sterilization on electrospun scaffolds constructed from biodegradable polyesters. Different fibrous layers fabricated from polycaprolactone (PCL) and a copolymer consisting of polylactide and polycaprolactone (PLCL) were investigated for the determination of their mechanical properties, degradation rates and interaction with fibroblasts. It was discovered that the sterilization procedure influenced the mechanical properties of the electrospun PLCL copolymer scaffold to the greatest extent. No effect of ethylene oxide sterilization on degradation behavior was observed. However, a delayed fibroblast proliferation rate was noticed with concern to the ethylene oxide sterilized samples compared to the ethanol sterilization of the materials.
References provided by Crossref.org
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- $a Horakova, J $u Department of Nonwovens and Nanofibrous Materials, Faculty of Textile Engineering, Technical University of Liberec, Studentska 1402/2, 461 17 Liberec, Czech Republic. Electronic address: jana.horakova@tul.cz.
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- $a The effect of ethylene oxide sterilization on electrospun vascular grafts made from biodegradable polyesters / $c J. Horakova, P. Mikes, A. Saman, V. Jencova, A. Klapstova, T. Svarcova, M. Ackermann, V. Novotny, T. Suchy, D. Lukas,
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- $a The study describes the detailed examination of the effect of ethylene oxide sterilization on electrospun scaffolds constructed from biodegradable polyesters. Different fibrous layers fabricated from polycaprolactone (PCL) and a copolymer consisting of polylactide and polycaprolactone (PLCL) were investigated for the determination of their mechanical properties, degradation rates and interaction with fibroblasts. It was discovered that the sterilization procedure influenced the mechanical properties of the electrospun PLCL copolymer scaffold to the greatest extent. No effect of ethylene oxide sterilization on degradation behavior was observed. However, a delayed fibroblast proliferation rate was noticed with concern to the ethylene oxide sterilized samples compared to the ethanol sterilization of the materials.
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- $a Mikes, P $u Department of Nonwovens and Nanofibrous Materials, Faculty of Textile Engineering, Technical University of Liberec, Studentska 1402/2, 461 17 Liberec, Czech Republic. Electronic address: petr.mikes@tul.cz.
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- $a Saman, A $u Department of Nonwovens and Nanofibrous Materials, Faculty of Textile Engineering, Technical University of Liberec, Studentska 1402/2, 461 17 Liberec, Czech Republic. Electronic address: ales.saman@tul.cz.
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- $a Jencova, V $u Department of Nonwovens and Nanofibrous Materials, Faculty of Textile Engineering, Technical University of Liberec, Studentska 1402/2, 461 17 Liberec, Czech Republic. Electronic address: vera.jencova@tul.cz.
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- $a Klapstova, A $u Department of Nonwovens and Nanofibrous Materials, Faculty of Textile Engineering, Technical University of Liberec, Studentska 1402/2, 461 17 Liberec, Czech Republic. Electronic address: andrea.klapstova@tul.cz.
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- $a Svarcova, T $u Department of Nonwovens and Nanofibrous Materials, Faculty of Textile Engineering, Technical University of Liberec, Studentska 1402/2, 461 17 Liberec, Czech Republic. Electronic address: tereza.svarcova@tul.cz.
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- $a Ackermann, M $u Department of Industrial Technology, Institute of Nanomaterials, Advanced Technologies and Innovation, Technical University of Liberec, Studentska 1402/2, 460 01 Liberec, Czech Republic. Electronic address: michal.ackermann@tul.cz.
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- $a Novotny, V $u Department of Nanomaterials in Natural Sciences, Institute of Nanomaterials, Advanced Technologies and Innovation, Technical University of Liberec, Liberec, Czech Republic. Electronic address: vit.novotny@tul.cz.
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- $a Suchy, T $u The Czech Academy of Sciences, Institute of Rock Structure and Mechanics, V Holesovickach 94/41, 182 09 Prague, Czech Republic. Electronic address: suchyt@irsm.cas.cz.
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- $a Lukas, D $u Department of Nonwovens and Nanofibrous Materials, Faculty of Textile Engineering, Technical University of Liberec, Studentska 1402/2, 461 17 Liberec, Czech Republic. Electronic address: david.lukas@tul.cz.
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