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Early cellular responses of germ-free and specific-pathogen-free mice to Francisella tularensis infection
Z. Krocova, L. Plzakova, M. Benuchova, A. Macela, K. Kubelkova,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
- MeSH
- bakteriální vakcíny imunologie MeSH
- cytokiny metabolismus MeSH
- Francisella tularensis imunologie patogenita MeSH
- gnotobiologické modely imunologie MeSH
- interakce hostitele a patogenu imunologie MeSH
- mikrobiota MeSH
- modely nemocí na zvířatech MeSH
- myši inbrední BALB C MeSH
- myši MeSH
- organismy bez specifických patogenů imunologie MeSH
- peritoneum mikrobiologie patologie MeSH
- přirozená imunita MeSH
- slezina mikrobiologie patologie MeSH
- tularemie imunologie mikrobiologie patologie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Bacteria that are highly virulent, expressing high infectivity, and able to survive nebulization, pose great risk to the human population. One of these is Francisella tularensis, the etiological agent of tularemia. F. tularensis is a subject of intense scientific interest due to the fact that vaccines for its immunoprophylaxis in humans are not yet routinely available. One of the substantial obstacles in developing such vaccines is our insufficient knowledge of processes that initiate and regulate the expression of effective protective immunity against intracellular bacteria. Here, we present data documenting the different pattern of cellular behavior occurring in an environment unaffected by microbiota using the model of germ-free mice mono-associated with F. tularensis subsp. holarctica strain LVS in comparison with a classic specific-pathogen-free murine model during early stages of infection.
Citace poskytuje Crossref.org
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- $a Krocova, Zuzana $u Department of Molecular Pathology and Biology, Faculty of Military Health Sciences, University of Defence, 1575 Trebesska, 500 01, Hradec Kralove, Czech Republic.
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- $a Bacteria that are highly virulent, expressing high infectivity, and able to survive nebulization, pose great risk to the human population. One of these is Francisella tularensis, the etiological agent of tularemia. F. tularensis is a subject of intense scientific interest due to the fact that vaccines for its immunoprophylaxis in humans are not yet routinely available. One of the substantial obstacles in developing such vaccines is our insufficient knowledge of processes that initiate and regulate the expression of effective protective immunity against intracellular bacteria. Here, we present data documenting the different pattern of cellular behavior occurring in an environment unaffected by microbiota using the model of germ-free mice mono-associated with F. tularensis subsp. holarctica strain LVS in comparison with a classic specific-pathogen-free murine model during early stages of infection.
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